Evidence map›Paper›PMID 41830965›Full record

ReviewActa neurologica Belgica2026

Stereotactic radiosurgery for central nervous system lymphoma: a systematic review and meta-analysis.

Bardia Hajikarimloo, Ibrahim Mohammadzadeh, Salem M Tos, Ali Mortezaei, Mohammadamin Sabbagh Alvani, Alireza Kooshki, Mohammad Amin Habibi

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In one paragraph

Review in Acta neurologica Belgica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Bardia HajikarimlooDepartment of Neurological Surgery, University of Virginia, Charlottesville, VA, USA. bardii47@yahoo.com.
Ibrahim MohammadzadehSkull Base Research Center, Loghman-Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Salem M TosDepartment of Neurological Surgery, University of Virginia, Charlottesville, VA, USA.
Ali MortezaeiStudent Research Committee, Gonabad University of Medical Sciences, Gonabad, Iran.
Mohammadamin Sabbagh AlvaniDepartment of Neurological Surgery, Shohada Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Alireza KooshkiStudent Research Committee, Birjand University of Medical Sciences, Birjand, Iran.
Mohammad Amin HabibiDepartment of Neurosurgery, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCentral nervous system lymphomas (CNSL) are aggressive and rare malignancies that are associated with a poor prognosis and limited treatment options. While high-dose methotrexate (HD-MTX) and whole-brain radiotherapy (WBRT) are primary options, they are correlated with recurrence and neurotoxicity. Stereotactic radiosurgery (SRS) has emerged as a potential targeted option; however, its effectiveness in CNSL remains largely unexplored. This study aimed to evaluate the role of SRS in CNSLs.

methodsA systematic search was conducted in PubMed, Embase, Scopus, and Web of Science. Studies reporting local control (LC), progression-free survival (PFS), overall survival (OS), distant brain failure (DBF), and adverse radiation effects (ARE) were included.

resultsSixteen studies involving 321 patients and 462 lesions were analyzed. The pooled LC was 97% (95% CI: 94%-100%), and the DBF rate was 58% (95% CI: 43%-72%). The PFS at 6, 12, and 24 months was 75% (95% CI: 67%-83%), 54% (95% CI: 44%-63%), and 29% (95% CI: 13%-48%), while the OS was 90% (95% CI: 78%-98%), 73% (95% CI: 56%-88%), and 42% (95% CI: 26%-59%). The pooled ARE rate was 7% (95% CI: 4%-11%). Human immunodeficiency virus (HIV)-positive status and larger tumor size were associated with less favorable outcomes.

conclusionSRS is associated with promising clinical and radiologic outcomes and low ARE rates in patients with CNSL, serving as a complementary or salvage option.

Indexed as

Central Nervous System LymphomaLocal ControlMeta-AnalysisStereotactic RadiosurgeryWhole-Brain Radiotherapy

Identifiers

PMID41830965

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.