Evidence map›Paper›PMID 41830670›Full record

ArticleRedox biology2026

Alexander disease mutations differentially sensitize glial fibrillary acidic protein (GFAP) to posttranslational modifications and network disruption by oxidants.

Nuria Goya-Iglesias, Per Hägglund, Paula Martínez-Cenalmor, Tina Nybo, Lasse G Lorentzen, María A Pajares, Michael J Davies, Dolores Pérez-Sala

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Redox biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Nuria Goya-IglesiasDepartment of Molecular and Cellular and Biosciences, Centro de Investigaciones Biológicas Margarita Salas, C.S.I.C., Madrid, 28040, Spain.
Per HägglundDepartment of Biomedical Sciences, Panum Institute, University of Copenhagen, Copenhagen, 2200, Denmark.
Paula Martínez-CenalmorDepartment of Molecular and Cellular and Biosciences, Centro de Investigaciones Biológicas Margarita Salas, C.S.I.C., Madrid, 28040, Spain.
Tina NyboDepartment of Biomedical Sciences, Panum Institute, University of Copenhagen, Copenhagen, 2200, Denmark.
Lasse G LorentzenDepartment of Biomedical Sciences, Panum Institute, University of Copenhagen, Copenhagen, 2200, Denmark.
María A PajaresDepartment of Molecular and Cellular and Biosciences, Centro de Investigaciones Biológicas Margarita Salas, C.S.I.C., Madrid, 28040, Spain.
Michael J DaviesDepartment of Biomedical Sciences, Panum Institute, University of Copenhagen, Copenhagen, 2200, Denmark. Electronic address: davies@sund.ku.dk.
Dolores Pérez-SalaDepartment of Molecular and Cellular and Biosciences, Centro de Investigaciones Biológicas Margarita Salas, C.S.I.C., Madrid, 28040, Spain. Electronic address: dperezsala@cib.csic.es.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The type III intermediate filament protein glial fibrillary acidic protein (GFAP) plays a key role in astrocyte and brain homeostasis. Mutations in GFAP can result in Alexander's disease (AxD), a severe neurodegenerative disease. Studies on AxD models indicate that oxidative stress may be an important pathogenic factor. Cellular expression of certain GFAP AxD mutants can provoke oxidative stress and contribute to a pathogenic cycle, as GFAP itself is an important oxidant target. To understand the molecular mechanisms involved, we have carried out a detailed LC-MS/MS characterization of posttranslational modifications formed on recombinant GFAP wild-type and AxD-relevant mutants (R79C, R239C and E373K) in response to in vitro treatment with hydrogen peroxide (H

Indexed as

Alexander DiseaseGlial Fibrillary Acidic ProteinMutationOxidantsProtein Processing, Post-TranslationalHumansHydrogen PeroxideOxidative StressGFAP protein, humanGlial Fibrillary Acidic ProteinHydrogen PeroxideOxidantsAlexander disease (AxD)Cysteine oxidationGlial fibrillary acidic protein (GFAP)Hydrogen peroxidePosttranslational modifications (PTMs)Protein oxidationProteomicsVimentin

Identifiers

PMID41830670
PMCPMC12996815

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.