Evidence map›Paper›PMID 41830539›Full record

ArticleChemistry & biodiversity2026

GABAergic Modulation and Neurobehavioral Effects of Arjunolic Acid, a Pentacyclic Triterpene Isolated From Combretum Mellifluum Eichler: In Vivo and Molecular Docking Evaluation.

Yanna Julie da Silva Freitas, Jéssica Bezerra Maciel, Maria Eduarda Uchoa Bezerra, Victor Moreira de Oliveira, Simone Alves Serafim Rocha, Otília Loiola Pessoa, Marcia Machado Marinho, Emmanuel Silva Marinho, Cléia Rocha de Sousa Feitosa, Jane Eire Silva Alencar de Menezes and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yanna Julie da Silva FreitasGraduate Program in Natural Sciences, State University of Ceará, Fortaleza, Ceará, Brazil.
Jéssica Bezerra MacielGraduate Program in Natural Sciences, State University of Ceará, Fortaleza, Ceará, Brazil.
Maria Eduarda Uchoa BezerraGraduate Program in Natural Sciences, State University of Ceará, Fortaleza, Ceará, Brazil.
Victor Moreira de OliveiraGraduate Program in Natural Sciences, State University of Ceará, Fortaleza, Ceará, Brazil.
Simone Alves Serafim RochaDepartment of Organic and Inorganic Chemistry, Federal University of Ceará, Fortaleza, Ceará, Brazil.
Otília Loiola PessoaDepartment of Organic and Inorganic Chemistry, Federal University of Ceará, Fortaleza, Ceará, Brazil.
Marcia Machado MarinhoGraduate Program in Natural Sciences, State University of Ceará, Fortaleza, Ceará, Brazil.
Emmanuel Silva MarinhoGraduate Program in Natural Sciences, State University of Ceará, Fortaleza, Ceará, Brazil.
Cléia Rocha de Sousa FeitosaGraduate Program in Natural Sciences, State University of Ceará, Fortaleza, Ceará, Brazil.
Jane Eire Silva Alencar de MenezesGraduate Program in Natural Sciences, State University of Ceará, Fortaleza, Ceará, Brazil.
Andreia Ferreira de Castro GomesCenter For Molecular and Environmental Biology, School of Sciences, Department of Biology, University of Minho, Braga, Portugal.
Hélcio Silva Dos SantosGraduate Program in Natural Sciences, State University of Ceará, Fortaleza, Ceará, Brazil.ORCID https://orcid.org/0000-0001-5527-164X

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorFUNCAP-INTERNACIONALIZAÇÃO ITR-0214-00060.01.00/23Fundação Cearense de Apoio ao Desenvolvimento Científico e Tecnológico
6 · The paper itself

Abstract

This study investigated the neuropharmacological effects of arjunolic acid, with a particular focus on its anxiolytic and anticonvulsant properties. To this end, in vivo tests were performed on adult zebrafish (Danio rerio) and in silico molecular docking analyses were conducted. Acute toxicity (96 h) was evaluated with doses of 4, 20, and 40 mg/kg (i.p.). Motor activity and anxiety levels induced by the different doses were evaluated using open field and light/dark tests, while the anticonvulsant potential was tested by induction with pentylenetetrazol (PTZ). The GABAergic neuromodulation was also investigated using the antagonist flumazenil and the molecular interaction with the GABA

Indexed as

Anti-Anxiety AgentsAnticonvulsantsMolecular Docking SimulationReceptors, GABA-ATriterpenesAnimalsBehavior, AnimalCarbonic Anhydrase IIDose-Response Relationship, DrugMalePentylenetetrazoleSeizuresStructure-Activity RelationshipZebrafishAnti-Anxiety AgentsAnticonvulsantsarjunolic acidCarbonic Anhydrase IIPentylenetetrazoleReceptors, GABA-ATriterpenesanticonvulsantanxiolyticGABA receptorterpenetriterpene

Identifiers

PMID41830539
PMCPMC12988567

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.