ArticleEpilepsia2026
Arterial spin labeling performs comparably to 2-[
Article in Epilepsia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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Authors and funding
8 authors.
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Abstract
objectiveThis study was undertaken to test whether arterial spin labeling (ASL) performs comparably to 2-[
methodsWe retrospectively included children with epilepsy due to focal cortical dysplasia, low-grade epilepsy-associated tumors, or hippocampal sclerosis who underwent standardized magnetic resonance imaging (MRI; including single-delay ASL) and FDG-PET during presurgical evaluation. Lesions, perilesional perfusion, and metabolic abnormalities were segmented and coregistered. Spatial overlap was quantified using DICE scores to compare functional modalities with each other (perfusion-to-metabolism: DICE
resultsFifteen children were included; median ages at FDG-PET and ASL were 7.7 and 7.5 years; 53% required sedation. Median perilesional volumes were 11 339 mm SIGNIFICANCE: ASL yielded perilesional findings equivalent to FDG-PET and showed comparable overlap with the resection cavity in seizure-free children. As a radiation-free technique embedded into routine MRI, ASL reduces logistics and avoids an additional sedation session. These findings support ASL as a practical alternative to FDG-PET for presurgical workup, especially when FDG-PET access is limited.
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