ArticleThe FEBS journal2026
Spatiotemporal dynamics of β-arrestin-mediated Src activation in 5-HT7 receptor signaling pathway.
Article in The FEBS journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
G protein-coupled receptors (GPCRs) initiate G protein-mediated signaling pathways upon ligand binding and are desensitized via β-arrestin-dependent internalization. However, emerging evidence indicates that β-arrestin also mediates G protein-independent signaling pathways that lead to distinct cellular responses. This signaling complexity has led to the development of GPCR-biased ligands that selectively modulate either G protein- or β-arrestin-dependent pathways for drug discovery, offering precise control of cellular processes with minimal side effects. We have developed biased ligands for the 5-hydroxytryptamine receptor subtype 7 (5-HT
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