Evidence map›Paper›PMID 41830509›Full record

ReviewAmerican journal of hematology2026

The Epidemiology of Sickle Cell Disease in Sub-Saharan Africa: Current Knowledge and Gaps to be Filled.

Brigitte Ranque, Leon Tshilolo, Thomas N Williams

Abstract readReview
In one paragraph

Review in American journal of hematology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Brigitte RanqueInternal Medicine Department, Hôpital Européen Georges Pompidou, Assistance Publique Des Hôpitaux de Paris, Initiatives IdEx Globule Rouge D'Excellence (InIdex GR-Ex), Université Paris Cité, Paris, France.ORCID 0000-0001-8549-2275
Leon TshiloloInstitut de Recherche Biomédicale 1 Health, Kinshasa; Pediatrics Department, Université Officielle de Mbujimayi, Mbujimayi, Democratic Republic of the Congo.ORCID 0000-0002-6318-0227
Thomas N WilliamsKEMRI-Wellcome Trust Research Programme, Kilifi, Kenya, Institute of Global Health Innovation, Imperial College, London, UK.ORCID 0000-0003-4456-2382

Funding

Wellcome Trust Senior Fellowship (202800/Z/16/Z)
6 · The paper itself

Abstract

Sickle Cell Disease (SCD) is highly prevalent in sub-Saharan Africa. Epidemiological data remain sparse, but regional screening and research initiatives are expanding. Due to genetic, environmental, and socioeconomic factors, the disease course differs markedly from that in high-income countries. Although mortality is improving and can be further lowered with simple interventions, it remains high, especially among undiagnosed children. Genetic factors, poor healthcare infrastructure, and poverty contribute to disease severity. While recent collaborative programs like SickleInAfrica offer hope, national policies that foster the training of healthcare workers, newborn screening, and access to treatment are crucial to reducing the burden of SCD across the region.

Indexed as

Anemia, Sickle CellAfrica South of the SaharaHumansInfant, NewbornNeonatal ScreeningPrevalenceSocioeconomic FactorsSub-Saharan African Peoplemorbiditymortalityoutcomesickle cell diseaseSubSaharan Africa

Identifiers

PMID41830509
PMCPMC12988571

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.