ArticleAmerican journal of physiology. Renal physiology2026
Glomerular hyperfiltration and enhanced sensitivity to kidney ischemia reperfusion with a blunted KIM-1 response in young male aging-accelerated SAMP8 mice.
Helen A Goodluck, Sadhana Kanoo, Young Chul Kim, Natalia Lopez, Yuji Oe, Antonio Jose Martins Currais, Pamela Maher, Volker Vallon
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In one paragraphArticle in American journal of physiology. Renal physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
8 authors.
Helen A GoodluckDepartment of Medicine, University of California San Diego, VA San Diego Healthcare System, San Diego, California, United States.ORCID 0000-0001-5158-645X Sadhana KanooDepartment of Medicine, University of California San Diego, VA San Diego Healthcare System, San Diego, California, United States.
Young Chul KimDepartment of Medicine, University of California San Diego, VA San Diego Healthcare System, San Diego, California, United States.
Natalia LopezDepartment of Medicine, University of California San Diego, VA San Diego Healthcare System, San Diego, California, United States.
Yuji OeDepartment of Medicine, University of California San Diego, VA San Diego Healthcare System, San Diego, California, United States.
Pamela MaherSalk Institute, San Diego, California, United States.
Volker VallonDepartment of Medicine, University of California San Diego, VA San Diego Healthcare System, San Diego, California, United States.ORCID 0000-0002-9211-2063 Funding
Viral Vector Core (VVC)P30CA014195 · NCI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI Alan Saghatelian · 1985 to 2026
$82.8MProject 4: Interrogating and harnessing age-related IFN signaling and innate immunity in HCC prevention and therapyP01AG073084 · NIA · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI PETER D. ADAMS, GERALD SHADEL · 2021 to 2026
$13.6MSan Diego Nathan Shock CenterP30AG068635 · NIA · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI SHADEL, GERALD · 2020 to 2024
$6.0MUAB-UCSD O'Brien Center for Acute Kidney Injury ResearchU54DK137307 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Javier A. Neyra · 2023 to 2026
$4.4MThe Contribution of Kidney Disease to Age-Associated Cognitive DeclineRF1AG061296 · NIA · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI MAHER, PAMELA ANNE · 2019 to 2019
$3.2MGlomerular and Tubular Function in the Recovering KidneyR01DK132690 · NIDDK · VETERANS MEDICAL RESEARCH FDN/SAN DIEGO · PI SCOTT Culver THOMSON, Volker Vallon · 2023 to 2026
$1.7MA Hybrid Quadrupole-Orbitrap LC/MSS10OD021815 · OD · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI SAGHATELIAN, ALAN · 2016 to 2016
$580kHHS | NIH | National Institute on Aging (NIA) RF1AG061296HHS | NIH | NIDDK | Division of Diabetes, Endocrinology, and Metabolic Diseases (DEM) P54DK137307HHS | NIH | NIDDK | Division of Diabetes, Endocrinology, and Metabolic Diseases (DEM) R01DK132690Manpei Suzuki Diabetes FoundationNCI NIH HHS P30 CA014195NIA NIH HHS P01 AG073084NIA NIH HHS P30 AG068635NIA NIH HHS RF1 AG061296NIDDK NIH HHS R01 DK132690NIDDK NIH HHS U54 DK137307NIH HHS S10 OD021815U.S. Department of Veterans Affairs (VA)
6 · The paper itselfAbstract
To better understand the impact of accelerated aging on kidney function, we compared standard C57BL6 mice (C57BL6) with senescence-accelerated mouse-prone 8 mice (SAMP8). Young male SAMP8 (3 and 6 mo) showed glomerular hyperfiltration compared with C57BL6 (absolute and per body weight), followed by gradual glomerular filtration rate (GFR) decline, lower blood pressure, and enhanced mortality over the first 15 mo of life. This was associated with higher kidney, heart, and liver but not brain weights. Female SAMP8 likewise showed a faster early rise in body weight, higher organ weights, and a somewhat higher mortality, but GFR and blood pressure appeared unaltered versus C57BL6. Since GFR phenotype was stronger in male mice, they were subjected to bilateral renal artery clamping-induced kidney ischemia reperfusion (IR). One day after IR, young SAMP8 (3 mo) showed higher plasma creatinine and kidney VCAM1 expression and subsequent mortality but a blunted rise in kidney
Indexed as
Acute Kidney InjuryAgingGlomerular Filtration RateHepatitis A Virus Cellular Receptor 1KidneyReperfusion InjuryAge FactorsAnimalsApoptosisDisease Models, AnimalFemaleMaleMiceMice, Inbred C57BLHavcr1 protein, mouseHepatitis A Virus Cellular Receptor 1acute kidney injuryagingCHCHD2KIM-1SAMP8 mice
Identifiers
PMID41830488
PMCPMC13101887
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