Evidence map›Paper›PMID 41830318›Full record

ArticleActa paediatrica (Oslo, Norway : 1992)2026

Discharging Preterm Infants on Caffeine-Practise Variation Across Europe: Results of a Cross-Sectional Survey.

Martin Kuntz, Lina Raljevic, Katharina Bergmann, Daniel Matheisl, Hendryk Schneider, Hans Fuchs

Abstract read
In one paragraph

Article in Acta paediatrica (Oslo, Norway : 1992), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Martin KuntzDepartment of General Pediatrics, Adolescent Medicine and Neonatology, Medical Center and Faculty of Medicine, University of Freiburg, Germany.ORCID https://orcid.org/0000-0002-8231-2838
Lina RaljevicDepartment of General Pediatrics, Adolescent Medicine and Neonatology, Medical Center and Faculty of Medicine, University of Freiburg, Germany.ORCID https://orcid.org/0000-0001-5689-3125
Katharina BergmannDepartment of General Pediatrics, Adolescent Medicine and Neonatology, Medical Center and Faculty of Medicine, University of Freiburg, Germany.
Daniel MatheislDepartment of General Pediatrics, Adolescent Medicine and Neonatology, Medical Center and Faculty of Medicine, University of Freiburg, Germany.ORCID https://orcid.org/0009-0004-3091-8290
Hendryk SchneiderDepartment of General Pediatrics, Adolescent Medicine and Neonatology, Medical Center and Faculty of Medicine, University of Freiburg, Germany.ORCID https://orcid.org/0009-0008-5199-0266
Hans FuchsDepartment of General Pediatrics, Adolescent Medicine and Neonatology, Medical Center and Faculty of Medicine, University of Freiburg, Germany.ORCID https://orcid.org/0000-0003-1303-3699

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimCaffeine is the mainstay of treatment for apnea of prematurity, yet the optimal strategy and timing for discontinuation remain undefined. Marked inter-centre variation in the practise of discharging preterm infants home on caffeine therapy has been reported. We aimed to map current practises in Europe concerning discharge of preterm infants on caffeine therapy, including home-monitoring and strategies for discontinuing ambulatory therapy.

methodsA web-based three-part questionnaire was sent to 633 neonatal units in 36 European countries (July-October 2025). One response per unit was permitted. The survey collected data on policies and practises regarding discharge on caffeine, criteria for stopping therapy, and post-discharge monitoring. Responses were analysed descriptively.

resultsComplete responses were obtained from 125 units in 21, revealing wide variation in practise patterns. Fifty-eight per cent of participating centres reported discharging preterm infants on continued caffeine therapy at least occasionally. Among those units, 58% reported prescribing home-monitoring routinely for infants discharged on caffeine therapy. Overall, significant differences in practise existed between geographical regions but not between high- and low-volume centres.

conclusionsDischarging preterm infants on continued caffeine therapy is a widespread practise among neonatologists in Europe, with considerable variation among regions and differing strategies concerning home-monitoring and discontinuation of treatment.

Indexed as

ApneaCaffeineCentral Nervous System StimulantsInfant, Premature, DiseasesPatient DischargePractice Patterns, Physicians'Cross-Sectional StudiesEuropeHumansInfant, NewbornInfant, PrematureSurveys and QuestionnairesCaffeineCentral Nervous System Stimulantsapnea of prematuritycaffeinedischarge planningsurvey

Identifiers

PMID41830318
PMCPMC13250953

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.