Evidence map›Paper›PMID 41830313›Full record

ArticleEuropean journal of neurology2026

Clinical and Pathological Features of Vasculitic Neuropathy: A Single-Center Study in China.

Xiaoyu Zhou, Didi Shan, Bin Wu, Fuchen Liu, Dong Zhang, Pengfei Lin, Wei Li, Yuying Zhao, Chuanzhu Yan, Jingwen Xu

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Article in European journal of neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Xiaoyu ZhouDepartment of Neurology, Research Institute of Neuromuscular and Neurodegenerative Diseases, Qilu Hospital of Shandong University, Shandong Key Laboratory of Mitochondrial Medicine and Rare Diseases, Jinan, Shandong, China.
Didi ShanDepartment of Neurology, Research Institute of Neuromuscular and Neurodegenerative Diseases, Qilu Hospital of Shandong University, Shandong Key Laboratory of Mitochondrial Medicine and Rare Diseases, Jinan, Shandong, China.ORCID 0009-0006-4624-5646
Bin WuDepartment of Neurology, Research Institute of Neuromuscular and Neurodegenerative Diseases, Qilu Hospital of Shandong University, Shandong Key Laboratory of Mitochondrial Medicine and Rare Diseases, Jinan, Shandong, China.ORCID 0009-0007-1895-213X
Fuchen LiuDepartment of Neurology, Research Institute of Neuromuscular and Neurodegenerative Diseases, Qilu Hospital of Shandong University, Shandong Key Laboratory of Mitochondrial Medicine and Rare Diseases, Jinan, Shandong, China.ORCID 0000-0002-8882-4172
Dong ZhangDepartment of Neurology, Research Institute of Neuromuscular and Neurodegenerative Diseases, Qilu Hospital of Shandong University, Shandong Key Laboratory of Mitochondrial Medicine and Rare Diseases, Jinan, Shandong, China.
Pengfei LinDepartment of Neurology, Research Institute of Neuromuscular and Neurodegenerative Diseases, Qilu Hospital of Shandong University, Shandong Key Laboratory of Mitochondrial Medicine and Rare Diseases, Jinan, Shandong, China.
Wei LiDepartment of Neurology, Research Institute of Neuromuscular and Neurodegenerative Diseases, Qilu Hospital of Shandong University, Shandong Key Laboratory of Mitochondrial Medicine and Rare Diseases, Jinan, Shandong, China.
Yuying ZhaoDepartment of Neurology, Research Institute of Neuromuscular and Neurodegenerative Diseases, Qilu Hospital of Shandong University, Shandong Key Laboratory of Mitochondrial Medicine and Rare Diseases, Jinan, Shandong, China.ORCID 0000-0002-0695-3238
Chuanzhu YanDepartment of Neurology, Research Institute of Neuromuscular and Neurodegenerative Diseases, Qilu Hospital of Shandong University, Shandong Key Laboratory of Mitochondrial Medicine and Rare Diseases, Jinan, Shandong, China.ORCID 0000-0002-2191-5184
Jingwen XuDepartment of Neurology, Research Institute of Neuromuscular and Neurodegenerative Diseases, Qilu Hospital of Shandong University, Shandong Key Laboratory of Mitochondrial Medicine and Rare Diseases, Jinan, Shandong, China.ORCID 0009-0009-3011-0191

Funding

Key R&D Program of Shandong Province, China 2025CXPT133National Natural Science Foundation of China 81901278
6 · The paper itself

Abstract

backgroundVasculitic neuropathy (VN) is a disease in which vessel inflammation happens and injures peripheral nerves. Despite increasing awareness, features of VN in mainland China are still understudied.

objectiveTo characterize the clinical, pathological features and outcomes of VN in mainland China, and evaluate clinicopathological correlations:

methodsWe retrospectively reviewed records of VN patients diagnosed pathologically between June 1999 and December 2024, including demographic data, clinical manifestations, biopsy features, and outcomes.

results112 patients were totally included. All presented with axonal sensorimotor neuropathy, most commonly involving the tibial (90.63%) and peroneal (87.50%) nerves. Systemic VN (SVN) showed more frequent transmural inflammatory cell infiltration (ICI) than non-systemic VN (NSVN) (p = 0.046). Eosinophilic granulomatosis with polyangiitis (EGPA) was more common in VN without ICI than VN with ICI (p = 0.008). In SVN, the ICI-positive exhibited more severe distal upper limb weakness (p = 0.042) and higher thrombosis rates (p = 0.001) than ICI-negative. Of the 63 patients followed, 62 received glucocorticoids with or without immunosuppressants. Thirteen died from multi-organ complications (12 SVN and 1 NSVN), while others achieved remission. The 5-year all-survival rate was 80.23% (95% CI 66.83%- 88.66%).

conclusionsThis first large cohort of VN in mainland China delineates its clinical-pathological features. EGPA showed a lower diagnostic yield on biopsy, suggesting diverse mechanisms of vascular injury. Nerve biopsy remains the diagnostic gold standard. The overall prognosis of VN is relatively favorable, emphasizing the need for early recognition and treatment.

Indexed as

Peripheral Nervous System DiseasesVasculitisAdultAgedChinaFemaleHumansMaleMiddle AgedRetrospective StudiesChinese cohortclinicopathological correlationprognostic factorssural nerve biopsyvasculitic neuropathy

Identifiers

PMID41830313
PMCPMC13140463

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