Evidence map›Paper›PMID 41830176›Full record

ArticleInfluenza and other respiratory viruses2026

Cross-Reactive IgG Antibody Responses to SARS-CoV-2 in Older Adults Following Seasonal Coronavirus Infection in Jiangsu, China (2015-2017).

Cheng Xiao, Nancy H L Leung, Shiman Ling, Xia Lin, Yuyun Chen, Yanmin Xie, Malik Peiris, Mark Zanin, Benjamin Cowling, Sook-San Wong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Influenza and other respiratory viruses, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Cheng XiaoHKU-Pasteur Research Pole, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.ORCID https://orcid.org/0009-0002-9245-5995
Nancy H L LeungWHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.
Shiman LingState Key Laboratory for Respiratory Diseases, Guangzhou Medical University, Guangzhou, China.
Xia LinHKU-Pasteur Research Pole, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.
Yuyun ChenWHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.
Yanmin XieWHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.
Malik PeirisSchool of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.
Mark ZaninSchool of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.
Benjamin CowlingWHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.ORCID https://orcid.org/0000-0002-6297-7154
Sook-San WongHKU-Pasteur Research Pole, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.ORCID https://orcid.org/0000-0002-1290-191X

Funding

Hong Kong SAR Government T11-705/21-NUS Centers for Disease Control and Prevention IP001064-01
6 · The paper itself

Abstract

The extent of cross-reactive antibodies to SARS-CoV-2 elicited by seasonal human coronaviruses (HCoVs) remains unclear. We analyzed longitudinal preinfection and postinfection IgG responses in 62 older adults with PCR-confirmed HCoV infections from sera collected prior to the emergence of SARS-CoV-2. At baseline, 12.9% and 16.1% had low-titer antibodies against SARS-CoV-2 spike (S) or nucleocapsid (N) proteins, respectively, but postinfection increases were marginal. Our findings suggest seasonal HCoV infections induce limited SARS-CoV-2 cross-reactive antibodies in community-dwelling older adults.

Indexed as

Antibodies, ViralImmunoglobulin GAgedAged, 80 and overChinaCOVID-19Cross ReactionsFemaleHumansMaleNucleocapsid ProteinsPandemicsSARS-CoV-2SeasonsSpike Glycoprotein, CoronavirusAntibodies, ViralImmunoglobulin GNucleocapsid ProteinsSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2

Identifiers

PMID41830176
PMCPMC13098167

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.