Evidence map›Paper›PMID 41829985›Full record

ArticleNutrients2026

A Novel Polysaccharide (ZJP-2) from Wild Jujube Alleviates Oxidative Damage in Neural Stem Cells: Structural Features and Bioactivity.

Shilan Li, Qiting Zhang, Jixian Liu, Xuchen Zhou, Ning Wang, Huabiao Chen, Nuermaimaiti Abudukelimu, Munisa Dilixiati, Xing Zhang, Xinmin Liu

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In one paragraph

Article in Nutrients, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Shilan LiZhejiang-Pakistan Joint Laboratory on R&D of Herbal Medicines, Institute of Drug Discovery and Technology, Ningbo University, Ningbo 315211, China.
Qiting ZhangDepartment of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China.ORCID 0000-0001-8069-3975
Jixian LiuZhejiang-Pakistan Joint Laboratory on R&D of Herbal Medicines, Institute of Drug Discovery and Technology, Ningbo University, Ningbo 315211, China.ORCID 0009-0006-0392-0250
Xuchen ZhouZhejiang-Pakistan Joint Laboratory on R&D of Herbal Medicines, Institute of Drug Discovery and Technology, Ningbo University, Ningbo 315211, China.
Ning WangZhejiang-Pakistan Joint Laboratory on R&D of Herbal Medicines, Institute of Drug Discovery and Technology, Ningbo University, Ningbo 315211, China.ORCID 0000-0002-5625-5358
Huabiao ChenHealth BioMed Co., Ltd., Ningbo 315042, China.
Nuermaimaiti AbudukelimuXinjiang Technical Institute of Physics & Chemistry, Chinese Academy of Sciences, Urumqi 830063, China.
Munisa DilixiatiXinjiang Technical Institute of Physics & Chemistry, Chinese Academy of Sciences, Urumqi 830063, China.
Xing ZhangZhejiang-Pakistan Joint Laboratory on R&D of Herbal Medicines, Institute of Drug Discovery and Technology, Ningbo University, Ningbo 315211, China.ORCID 0009-0002-8152-1037
Xinmin LiuZhejiang-Pakistan Joint Laboratory on R&D of Herbal Medicines, Institute of Drug Discovery and Technology, Ningbo University, Ningbo 315211, China.

Funding

the Health Fund of Translational Biomedicine from Health BioMed Co., Ltd., Ningbo, Zhejiang, China H2024000279the Ningbo Top Talent Project No. 215-432094250the R&D of Drug and Health Products from Wild jujube, S&T Department, Xinjiang Government 2023A02010This research was supported by the research and development of functional products based on jujube as raw material and study on their mechanisms of action. Xinjiang Production and Construction Corps NGHJG Project 2023AA503
6 · The paper itself

Abstract

backgroundTraditionally, wild jujube (

methodsWe successfully isolated and purified a novel pectin polysaccharide (ZJP-2) from wild jujube. Its structure was characterized in detail using high-performance liquid chromatography coupled with multi-angle laser light scattering and refractive index detection (HPLC-MALS-RI), high-performance anion exchange chromatography (HPAEC), gas chromatography-mass spectrometry (GC-MS), and nuclear magnetic resonance (NMR) spectroscopy.

resultsStructural analysis revealed that ZJP-2 is a pectin heteropolysaccharide with a molecular weight of approximately 67.93 kDa. Its monosaccharide composition primarily includes galac-turonic acid (GalA), arabinose (Ara), rhamnose (Rha), galactose (Gal), and glucose (Glc). The backbone consists of α-GalA and rhamnose-galacturonic acid-I (RG-I) domains linked by (1→4)-glycosidic bonds. NMR spectroscopy further confirmed its glycosidic bond types. In activity assessment, our study demonstrated that ZJP-2 significantly alleviated DMNQ-induced oxidative stress damage in C17.2 neural stem cells. Its protective effect was achieved by reducing intracellular reactive oxygen species (ROS) levels and upregulating the mRNA expression of antioxidant genes associated with the signaling axis (

conclusionsIn conclusion, ZJP-2 possesses distinct structural characteristics and significant neuroprotective potential, supporting its development as a natural functional food or dietary supplement for preventing oxidative stress-related neural damage.

Indexed as

Neural Stem CellsOxidative StressPectinsPolysaccharidesZiziphusAnimalsAntioxidantsMiceNeuroprotective AgentsAntioxidantsNeuroprotective AgentsPectinsPolysaccharidesantioxidant activityneuroprotective effectpectic polysaccharidestructural characterizationwild jujube

Identifiers

PMID41829985
PMCPMC12986636

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