ArticleNutrients2026
A Longitudinal Study of the Effects of Ketogenic Diet on Seizures, Cardiorespiration, Sleep Architecture and Mortality in the Kv1.1 Knockout Mouse Model of Sudden Unexpected Death in Epilepsy (SUDEP).
Shruthi H Iyer, Stephanie A Matthews, Jodi Hallgren, Lauren Netzel, Timothy A Simeone, Kristina A Simeone
Abstract read
In one paragraphArticle in Nutrients, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
6 authors.
Shruthi H IyerDepartment of Pharmacology & Neuroscience, Creighton University School of Medicine, Omaha, NE 68178, USA.ORCID 0000-0002-7164-2495 Stephanie A MatthewsDepartment of Pharmacology & Neuroscience, Creighton University School of Medicine, Omaha, NE 68178, USA.
Jodi HallgrenDepartment of Pharmacology & Neuroscience, Creighton University School of Medicine, Omaha, NE 68178, USA.ORCID 0000-0002-3892-8213 Lauren NetzelDepartment of Pharmacology & Neuroscience, Creighton University School of Medicine, Omaha, NE 68178, USA.
Timothy A SimeoneDepartment of Pharmacology & Neuroscience, Creighton University School of Medicine, Omaha, NE 68178, USA.ORCID 0000-0002-8716-7211 Kristina A SimeoneDepartment of Pharmacology & Neuroscience, Creighton University School of Medicine, Omaha, NE 68178, USA.ORCID 0000-0001-5072-3694 Funding
Autoresuscitation and SUDEPR01NS126418 · NINDS · CREIGHTON UNIVERSITY · PI Kristina A Simeone, Timothy A. Simeone · 2022 to 2026
$1.7MMechanisms of SUDEP: Failure to AutoresuscitateR21NS111389 · NINDS · CREIGHTON UNIVERSITY · PI SIMEONE, KRISTINA A · 2020 to 2020
$400kNational Institutes of Health NINDS NS072179National Institutes of Health NINDS NS111389National Institutes of Health NINDS NS126418Nebraska State Biomedical Research Resources G20RR024001NINDS NIH HHS R01 NS126418NINDS NIH HHS R21 NS111389State of Nebraska LB692 Biomedical Research Development Fund Award
6 · The paper itselfAbstract
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Indexed as
Diet, KetogenicEpilepsyKv1.1 Potassium ChannelSeizuresSleepSudden Unexpected Death in EpilepsyAnimalsApneaBradycardiaDeath, SuddenDisease Models, AnimalHeart RateHypoxiaLongitudinal StudiesMaleMiceKcna1 protein, mouseKv1.1 Potassium Channelapneaepilepsyheart ratehypoxemiaKcna1-nullketogenic dietlongevitymetabolic therapyrespirationsudden unexpected deathSUDEP biomarkers
Identifiers
PMID41829979
PMCPMC12986616
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