Evidence map›Paper›PMID 41829969›Full record

ArticleNutrients2026

Quercetin and Derivatives Ameliorate Metabolic Disturbances by Regulating Gut Metabolite Profiles in Mice with Circadian Rhythm Disruption and High-Fat Diet.

Hao Jiang, Yiling Xie, Xiaoqing Zheng, Jiali Lai, Xiangyun Chen, Xiantao Zheng, Hongwei Zhao, Weidong Bai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hao JiangCollege of Food Science and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China.ORCID 0000-0001-8788-888X
Yiling XieCollege of Food Science and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China.
Xiaoqing ZhengCollege of Food Science and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China.
Jiali LaiCollege of Food Science and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China.
Xiangyun ChenCollege of Food Science and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China.
Xiantao ZhengCollege of Food Science and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China.
Hongwei ZhaoInfinitus (China) Co., Ltd., Guangzhou 510623, China.
Weidong BaiCollege of Food Science and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China.

Funding

Guangdong Province DoctoralWorkstation (No.60, [2024])Guangdong Province Key Research and DevelopmentProgram 2023B03J1307Linzhi City Science and Technology Planning Project ZYYDDFZX2025-02Technology Innovation Fund of Zhongkai University ofAgriculture and Engineering KA24YY07025"Ten Thousand Projects" Rural Science and Technology Specialists KTP20240971the China National Natural Science Foundation 32201959The Development and Reform and Industry andCommerce Bureau of Bomi County (No.401, [2025])
6 · The paper itself

Abstract

backgroundAmidst evolving modern lifestyles characterized by widespread circadian rhythm disturbances and high-fat dietary habits, the incidence of metabolic disorders continues to escalate. In recent years, plant-derived bioactive compounds have attracted considerable interest as therapeutic candidates, with quercetin and its derivatives demonstrating promising potential for the regulation of metabolism.

methodsThis study employed a dual-induction model of metabolic dysregulation, elicited through both circadian rhythm disruption and a high-fat diet, to systematically evaluate the regulatory effects of quercetin and its derivatives on mice through dual stimulation by circadian rhythm disruption and a high-fat diet. RESULTS AND

conclusionsNon-targeted fecal metabolomics analysis indicates that quercetin and its derivatives significantly alter the intestinal metabolite profile in mice, alleviating metabolic abnormalities induced by circadian rhythm disruption and high-fat diet. These findings provide a theoretical basis for the future development of quercetin-based functional food products.

Indexed as

Chronobiology DisordersCircadian RhythmDiet, High-FatMetabolic DiseasesMetabolomeQuercetinAnimalsFecesMaleMetabolomicsMiceMice, Inbred C57BLQuercetincircadian rhythm disordersintestinal metabolitesquercetin and its derivatives (isoquercitrin and enzymatically modified isoquercitrin)

Identifiers

PMID41829969
PMCPMC12986487

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.