Evidence map›Paper›PMID 41829940›Full record

Trial reportNutrients2026

An Infant Formula with Partially Hydrolyzed Whey and Intact Protein Demonstrates Adequate Growth and Safety: A 6-Month Randomized, Triple-Blind, Controlled Trial.

Qianqian Shen, Hua Jiang, Shuai Mao, Sha Luo, Yanjie Hao, Wenxin Liang, Tingchao He, Lotte Neergaard Jacobsen, Nan Sheng, Jing Yin and 4 more

Abstract readRandomized Controlled TrialMulticenter StudyEquivalence Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrients, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Qianqian ShenDepartment of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100191, China.ORCID 0009-0008-4452-649X
Hua JiangSchool of Nursing, Peking University, Beijing 100091, China.ORCID 0000-0002-3264-990X
Shuai MaoDepartment of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100191, China.
Sha LuoMaternal and Child Health Hospital of Changsha County, Changsha 410100, China.
Yanjie HaoDepartment of Neonatology, Shahe People's Hospital, Xingtai 054100, China.
Wenxin LiangDepartment of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100191, China.
Tingchao HeDepartment of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100191, China.
Lotte Neergaard JacobsenStrategic Business Unit Specialized Nutrition, Arla Foods Ingredients Group P/S, Viby J, 8260 Aarhus, Denmark.
Nan ShengJunlebao Dairy Joint Laboratory of Breast Milk Science and Life Health, Peking University, Beijing 100191, China.
Jing YinStrategic Business Unit Specialized Nutrition, Arla Foods Ingredients Group P/S, Viby J, 8260 Aarhus, Denmark.
Xiaoying FengJunlebao Dairy Joint Laboratory of Breast Milk Science and Life Health, Peking University, Beijing 100191, China.
Xiaojiang JiaJunlebao Dairy Joint Laboratory of Breast Milk Science and Life Health, Peking University, Beijing 100191, China.
Yvan VandenplasKidZ Health Castle, UZ Brussel, 1090 Brussels, Belgium.ORCID 0000-0002-1862-8651
Yumei ZhangDepartment of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100191, China.ORCID 0000-0002-0103-7900

Funding

Arla Foods (Denmark) NA
6 · The paper itself

Abstract

BACKGROUND/

objectivesEvidence suggests that partially hydrolyzed whey protein promotes appropriate infant growth; however, research on its long-term effects, especially in Asia, remains limited. This study set out to evaluate the effects of an infant formula containing partially hydrolyzed whey and intact protein on infant growth and development.

methodsThis multicenter, triple-blind, randomized non-inferiority trial enrolled healthy full-term infants (≤14 days old). Participants were randomized (1:1) to receive pHF (

resultsOver 6 months, the adjusted mean (SE) daily weight gain (g) was 26.4 (1.27) g/day in BF, 26.0 (1.19) g/day in pHF, and 25.3 (1.27) g/day in the SF group. The adjusted mean difference between pHF and SF was 0.64 g/day (95%CI: -1.55, 2.83), confirming non-inferiority. Growth parameters were comparable between pHF and SF, with WHO z-scores remaining within ±1 SD of reference standards. Compared with pHF, SF was associated with a slower increase in length-for-age z score (LAZ). While there was no difference between the pHF and BF groups, WAZ increased significantly less in SF vs. BF [-0.34 (95%CI: -0.58, -0.10),

conclusionsAn infant formula containing partially hydrolyzed whey and intact protein supported adequate growth and was well tolerated during the first six months of life, with growth trajectories comparable to those of breastfed infants.

Indexed as

Child DevelopmentInfant FormulaInfant Nutritional Physiological PhenomenaWhey ProteinsBreast FeedingFemaleHumansHydrolysisInfantInfant, NewbornMaleWeight GainWhey Proteinsbreast feedinggrowth and developmentgrowth trajectoriesinfant formulapartially hydrolyzed whey proteinrandomized controlled trial

Identifiers

PMID41829940
PMCPMC12986564

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.