Research on Denoising Methods for Laser Doppler Blood Flow Signals Based on Time-Domain Noise Perception and DWT.

Addressing the challenges of composite noise (speckle noise, thermal noise, and random pulse interference) and non-stationarity in laser Doppler flow (LDF) signal processing, as well as the technical limitation of traditional threshold methods in balancing noise suppression and signal fidelity, this study proposes an adaptive denoising algorithm integrating temporal noise perception and discrete wavelet transform (DWT). A composite noise model is first established to characterize the interference. The signal undergoes a five-level DWT decomposition, where a local energy detection mechanism distinguishes signal-dominant from noise-dominant regions. An SNR-driven dynamic thresholding strategy is generated by combining inter-layer adaptive allocation with coefficient-level local weighting, followed by processing with an improved smoothing function to effectively suppress reconstruction artifacts. Simulations at a 1 dB input signal-to-noise ratio (SNR) yielded a 15.45 dB output SNR and a 0.05634 root mean square error (RMSE), outperforming traditional wavelet methods and modern benchmarks such as local variance and variational mode decomposition (VMD). Applied to a practical signal from an isolated vascular phantom with an initial SNR of -1.04 dB, the algorithm achieved a 13.86 dB output SNR and a 0.00258 RMSE. Results confirm the algorithm's effectiveness for high-fidelity waveform capture in complex noise environments, offering a robust solution for vascular hemodynamic monitoring.