ReviewPolymers2026
Quaternized Chitosan Crosslinked Networks for pH-Responsive Macromolecule Delivery: A Review.
Review in Polymers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Chitosan, a biocompatible and biodegradable polysaccharide, exhibits notable antibacterial properties. However, its practical applications are often constrained by inherent limitations such as poor solubility (restricted to acidic media) and suboptimal mechanical strength. By constructing dynamic covalent networks with QCS and green crosslinkers (e.g., genipin, dialdehyde cellulose), materials acquire excellent pH-responsive intelligence. This review elaborates on the molecular design, crosslinking strategies, and applications in intelligent packaging and targeted therapy. The synergistic Schiff-base/hydrogen-bonding mechanism enables dual (pH/enzyme) responsive release. We clarify the relationship between quaternization degree and cytotoxicity as a key challenge for clinical translation and analyze how green crosslinkers are molecular bridges to tailor network properties. The 'perception-response' integrated design principle of QCS demonstrates significant potential for intelligent packaging and antibacterial-anticancer synergistic therapy, while addressing key biosafety considerations.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.