Class-Specific Immunochromatographic Assay Enabled by Mesoporous Nanozyme-Catalyzed Signal Amplification for On-Site Screening of Sulfonylureas.

Yanting Li, Zixian He, Pengjie He, Zixuan Tang, Esra Bağda, Efkan Bağda, Zhenlin Xu, Xiangmei Li

Abstract read

In one paragraph

Article in Foods (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

8 authors.

Yanting LiGuangdong Provincial Key Laboratory of Food Quality and Safety, College of Food Science, South China Agricultural University, Guangzhou 510642, China.

Zixian HeGuangdong Provincial Key Laboratory of Food Quality and Safety, College of Food Science, South China Agricultural University, Guangzhou 510642, China.

Pengjie HeGuangdong Provincial Key Laboratory of Food Quality and Safety, College of Food Science, South China Agricultural University, Guangzhou 510642, China.

Zixuan TangGuangdong Provincial Key Laboratory of Food Quality and Safety, College of Food Science, South China Agricultural University, Guangzhou 510642, China.

Esra BağdaDepartment of Basic Pharmaceutical Sciences, Analytical Chemistry Division, Faculty of Pharmacy, Sivas Cumhuriyet University, 58140 Sivas, Türkiye.

Efkan BağdaDepartment of Molecular Biology and Genetics, Faculty of Science, Sivas Cumhuriyet University, 58140 Sivas, Türkiye.

Zhenlin XuGuangdong Provincial Key Laboratory of Food Quality and Safety, College of Food Science, South China Agricultural University, Guangzhou 510642, China.ORCID 0000-0002-1197-4615

Xiangmei LiGuangdong Provincial Key Laboratory of Food Quality and Safety, College of Food Science, South China Agricultural University, Guangzhou 510642, China.

Funding

National Key Research and Development Program of China 2023YFF1105004National Natural Science Foundation of China 32272404National Natural Science Foundation of China 32572699

6 · The paper itself

Abstract

Conventional immunochromatographic assays (ICAs) face limitations in sensitivity and dynamic range, hindering their application in on-site, class-specific screening of sulfonylurea (SU) adulteration in functional foods. To address this, a signal amplification strategy was developed by engineering high-density platinum nanozymes on a mesoporous metal-organic framework (PCN-224). The mesoporous architecture of PCN-224 facilitated high-density and stable loading of catalytically active Pt sites. The established PCN-224@Pt-based ICA achieved detection limits of 0.52-7.94 μg/kg in tea and 0.69-7.02 μg/kg in capsules, with linear ranges of 1.69-513.01 μg/kg and 2.05-716.47 μg/kg, respectively. Compared with traditional colloidal gold immunochromatographic assays (CG-ICAs), sensitivity was improved by up to 57-fold, while the linear detection range was expanded by over 5-fold relative to the previously reported PCN-224@PDA- ICA. The method demonstrated recovery rates of 81.8-119.8% and coefficients of variation between 2.5% and 11.4%. Validation against LC-MS/MS using 20 real samples showed excellent agreement (R

Indexed as

functional foodsimmunochromatographic assaynanozymesPCN-224@Ptsulfonylureas

Identifiers

PMID41829217

DOI10.3390/foods15050944

PMCPMC12984563

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