Laccase-Mimicking Cu-Tannic Acid Nanozyme for Zearalenone Detoxification: Mechanism and Application in Corn Oil.

Hongfei Li, Zhiyong Rao, Minglu Guo, Xingke Zhang, Zhixiang Wang, Wei Zhang, Yongpeng Guo

Abstract read

In one paragraph

Article in Foods (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Hongfei LiCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China.

Zhiyong RaoCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China.

Minglu GuoCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China.

Xingke ZhangCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China.

Zhixiang WangCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China.

Wei ZhangCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China.ORCID 0000-0003-3851-3509

Yongpeng GuoCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China.

Funding

Key Scientific Research Project of Colleges and Universities of Henan Province 26A230005Major Science and Technology Special Program of Henan Province 251100110400Young Talents Fund of Henan Agricultural University 30501327

6 · The paper itself

Abstract

Zearalenone (ZEN), a prevalent estrogenic mycotoxin found in grains and oils, poses significant health risks due to its endocrine-disrupting properties. This study elucidates the application of a laccase-mimicking copper-tannic acid (CuTA) nanozyme as an effective catalyst for the degradation of ZEN. The CuTA nanozyme was capable of directly catalyzing the oxidation of ZEN, with optimal reaction conditions observed at a pH of 7.0 and temperatures ranging from 37 to 57 °C. The degradation products of ZEN were identified as 13-hydroxy-zearalenone (13-OH-ZEN) and 15-hydroxy-zearalenone (15-OH-ZEN). Furthermore, cytotoxicity assessments demonstrated that the CuTA nanozyme-mediated degradation of ZEN effectively reduced the hepatotoxicity of this mycotoxin. The E-screen bioassay revealed a 43.7-fold reduction in the estrogenic activity of ZEN after CuTA-mediated degradation. In corn oil, the CuTA nanozyme achieved 82% ZEN removal within 12 h and maintained 58% efficiency after four reuse cycles. These results highlight the potential use of the CuTA nanozyme to detoxify ZEN in corn oil.

Indexed as

corn oildegradationlaccasenanozymezearalenone

Identifiers

PMID41829101

DOI10.3390/foods15050828

PMCPMC12985296

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