Preventive and Ameliorative Effects of Alanine Supplementation on High-Fat Diet-Induced Obesity and Metabolic Dysfunction via the Gut-Liver-Adipose Axis in C57BL/6J Mice.

Yutong Sun, Xingyu Wang, Hongzhi Liu, Xinbo Zhou, Qingquan Ma

Abstract read

In one paragraph

Article in Foods (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yutong SunCollege of Animal Science and Technology, Northeast Agricultural University, Harbin 150036, China.

Xingyu WangCollege of Animal Science and Technology, Northeast Agricultural University, Harbin 150036, China.

Hongzhi LiuCollege of Animal Science and Technology, Northeast Agricultural University, Harbin 150036, China.

Xinbo ZhouCollege of Animal Science and Technology, Northeast Agricultural University, Harbin 150036, China.

Qingquan MaCollege of Animal Science and Technology, Northeast Agricultural University, Harbin 150036, China.

Funding

Heilongjiang Provincial "Double First-Class" Discipline Collaborative Innovation Project LJGXCG2022-024Heilongjiang Provincial Undergraduate University Outstanding Young Faculty Basic Research Support Program YQJH2025035National Natural Science Foundation of China 32372909Northeast Agricultural University Backbone Talent Introduction Program 54961212

6 · The paper itself

Abstract

The present study aimed to investigate the role of alanine (Ala) in regulating obesity and glucose homeostasis in C57BL/6J mice. Two independent experiments were conducted: a preventive model (Experiment 1: 10 weeks of concurrent high-fat diet (HFD) and Ala administration) and a therapeutic model (Experiment 2: 10 weeks of Ala treatment following a 10-week HFD-induced obesity period). In Experiment 1, Ala significantly attenuated HFD-induced weight gain (35.16 g vs. 30.82 g,

Indexed as

alanineglucosehigh-fat dietintestinal microbiotalipid

Identifiers

PMID41829079

DOI10.3390/foods15050806

PMCPMC12984193

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.