Rapid Discovery of CD38 Inhibitor via DNA-Encoded Natural Product Library Screening.

Xinyu Shi, Ze Liang, Wentao Meng, Guang Yang, Lei Yan

Abstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Structural dissection of CD38 antigen engagement by CAR binders and rational affinity tuning.iScience · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xinyu ShiState Key Laboratory of Microbial Technology, School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, Nanjing 210023, China.

Ze LiangState Key Laboratory of Microbial Technology, School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, Nanjing 210023, China.

Wentao MengState Key Laboratory of Microbial Technology, School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, Nanjing 210023, China.

Guang YangState Key Laboratory of Microbial Technology, School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, Nanjing 210023, China.

Lei YanShanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai 200120, China.ORCID 0000-0003-1775-5533

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CD38 is a multifunctional enzyme that plays a pivotal role in NAD

Indexed as

ADP-ribosyl Cyclase 1Biological ProductsDNADrug DiscoveryEnzyme InhibitorsMembrane GlycoproteinsSmall Molecule LibrariesHigh-Throughput Screening AssaysHumansMolecular Docking SimulationProtein BindingStructure-Activity RelationshipSurface Plasmon ResonanceADP-ribosyl Cyclase 1Biological ProductsCD38 protein, humanDNAEnzyme InhibitorsMembrane GlycoproteinsSmall Molecule LibrariesCD38DNA-encoded library (DEL)enzymatic activitymolecular dockingNAD+ metabolismsmall-molecule inhibitorstructure-activity relationship (SAR)

Identifiers

PMID41828851

DOI10.3390/molecules31050864

PMCPMC12986513

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.