A Novel Wogonin Derivative Induces Apoptosis in PC-3M Cells by Targeting Mitochondrial Dysfunction and Activating the ROS-p38/MAPK Pathway.

Dingrui Liu, Fangfei Liu, Mingjie Song, Fengyan Su, Wei Li, Yan Zhao, Jiahong Han, Enbo Cai

Abstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Dingrui LiuCollege of Chinese Medicinal Material, Jilin Agricultural University, 2888 Xincheng Street, Changchun 130118, China.ORCID 0000-0002-8894-2494

Fangfei LiuCollege of Chinese Medicinal Material, Jilin Agricultural University, 2888 Xincheng Street, Changchun 130118, China.

Mingjie SongCollege of Chinese Medicinal Material, Jilin Agricultural University, 2888 Xincheng Street, Changchun 130118, China.

Fengyan SuCollege of Chinese Medicinal Material, Jilin Agricultural University, 2888 Xincheng Street, Changchun 130118, China.

Wei LiCollege of Chinese Medicinal Material, Jilin Agricultural University, 2888 Xincheng Street, Changchun 130118, China.ORCID 0000-0002-2988-4298

Yan ZhaoCollege of Chinese Medicinal Material, Jilin Agricultural University, 2888 Xincheng Street, Changchun 130118, China.ORCID 0000-0003-0704-7410

Jiahong HanCollege of Chinese Medicinal Material, Jilin Agricultural University, 2888 Xincheng Street, Changchun 130118, China.

Enbo CaiCollege of Chinese Medicinal Material, Jilin Agricultural University, 2888 Xincheng Street, Changchun 130118, China.ORCID 0000-0002-6355-7071

Funding

Project of Natural Science Foundation of Jilin Province 20260102117JC

6 · The paper itself

Abstract

Current cancer treatments have significant limitations. Designing TPP

Indexed as

Antineoplastic AgentsApoptosisFlavanonesMAP Kinase Signaling SystemMitochondriap38 Mitogen-Activated Protein KinasesReactive Oxygen SpeciesCell Line, TumorHumansMembrane Potential, MitochondrialPC-3 CellsAntineoplastic AgentsFlavanonesp38 Mitogen-Activated Protein KinasesReactive Oxygen Specieswogoninapoptosismitochondrial targetingPC-3MROS-p38/MAPK pathwaywogonin

Identifiers

PMID41828845

DOI10.3390/molecules31050859

PMCPMC12985526

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.