Evidence map›Paper›PMID 41828835›Full record

ArticleMolecules (Basel, Switzerland)2026

Late-Stage Functionalization of the Rifamycin Core via Click Chemistry Toward New Antibacterial Derivatives.

Lola Beeser, Daniel Armstrong, Marissa S Fullerton, Isabella Beasley, Wyatt Treadway, Clara Nikkel, Mai Lan Ho, Braden Glenn, Catherine Mills, Shailesh Budhathoki and 9 more

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Lola BeeserDivision of Natural Sciences, Lyon College, Batesville, AR 72501, USA.
Daniel ArmstrongDivision of Natural Sciences, Lyon College, Batesville, AR 72501, USA.
Marissa S FullertonDepartment of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Isabella BeasleyDivision of Natural Sciences, Lyon College, Batesville, AR 72501, USA.
Wyatt TreadwayDivision of Natural Sciences, Lyon College, Batesville, AR 72501, USA.
Clara NikkelDivision of Natural Sciences, Lyon College, Batesville, AR 72501, USA.
Mai Lan HoDivision of Natural Sciences, Lyon College, Batesville, AR 72501, USA.
Braden GlennDivision of Natural Sciences, Lyon College, Batesville, AR 72501, USA.
Catherine MillsDivision of Natural Sciences, Lyon College, Batesville, AR 72501, USA.ORCID 0009-0007-7189-4426
Shailesh BudhathokiMolecular Biosciences Program, Arkansas State University, Jonesboro, AR 72401, USA.
Jessie ParchmanDivision of Natural Sciences, Lyon College, Batesville, AR 72501, USA.
Ryan HoldinessDivision of Natural Sciences, Lyon College, Batesville, AR 72501, USA.
Jake SmithDivision of Natural Sciences, Lyon College, Batesville, AR 72501, USA.
Zachary HodgeDivision of Natural Sciences, Lyon College, Batesville, AR 72501, USA.
Amanda L DraganDepartment of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Mohammad Abrar AlamMolecular Biosciences Program, Arkansas State University, Jonesboro, AR 72401, USA.ORCID 0000-0003-0258-3732
Robert C ShieldsDepartment of Oral Biology, University of Florida, Gainesville, FL 32610, USA.ORCID 0000-0002-8823-9504
Daniel E VothDepartment of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Irosha N NawarathneDivision of Natural Sciences, Lyon College, Batesville, AR 72501, USA.ORCID 0000-0002-7104-3556

Funding

The Arkansas IDeA Network of Biomedical Research Excellence (AR INBRE) and the Research Technology Core of the Arkansas INBRE program, supported by a grant from the National Institute of General Medical Sciences (NIGMS), P20GM103429 from the National Inst P20GM103429
6 · The paper itself

Abstract

Antimicrobial resistance (AMR) threatens global health, particularly through the rise of multidrug-resistant tuberculosis (MDR-TB) and other critical bacterial infections such as methicillin-resistant

Indexed as

Anti-Bacterial AgentsClick ChemistryRifamycinsMethicillin-Resistant Staphylococcus aureusMicrobial Sensitivity TestsMolecular StructureStructure-Activity RelationshipAnti-Bacterial AgentsRifamycinsantibacterialclick chemistryenabling reactionrifamycinrifamycin S

Identifiers

PMID41828835
PMCPMC12985754

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.