Evidence map›Paper›PMID 41828832›Full record

ArticleMolecules (Basel, Switzerland)2026

Stability and Reactivity of Alternative Nucleobases in Concentrated Sulfuric Acid.

Jingcheng Huang, Sara Seager, Maxwell D Seager, Janusz J Petkowski

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jingcheng HuangDepartment of Earth, Atmospheric and Planetary Sciences, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.ORCID 0000-0001-5732-8531
Sara SeagerDepartment of Earth, Atmospheric and Planetary Sciences, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.ORCID 0000-0002-6892-6948
Maxwell D SeagerNanoplanet Consulting, Concord, MA 01742, USA.ORCID 0009-0009-1111-6854
Janusz J PetkowskiFaculty of Environmental Engineering, Wroclaw University of Science and Technology, 50-370 Wroclaw, Poland.ORCID 0000-0002-1921-4848

Funding

Nanoplanet Consulting N/AThe Alfred P. Sloan Foundation G-2023-20929The Volkswagen Foundation 9E126
6 · The paper itself

Abstract

Recent findings demonstrate that concentrated sulfuric acid supports rich organic chemistry, including the stability of the canonical DNA bases adenine, thymine, guanine and cytosine. Yet, due to full protonation in concentrated sulfuric acid, these bases may not pair as effectively as they do in water. We are therefore motivated to study nucleic acid bases that pair via hydrophobic and van der Waals interactions instead of canonical hydrogen bonding. Here, we investigate the stability of 14 selected, commercially available alternative nucleobases in concentrated sulfuric acid to evaluate their potential for forming DNA-like polymers in this solvent. The reactivity of compounds

Indexed as

DNASulfuric AcidsAdenineCytosineGuanineHydrogen BondingHydrophobic and Hydrophilic InteractionsMagnetic Resonance SpectroscopyThymineAdenineCytosineDNAGuaninesulfuric acidSulfuric AcidsThymine13C NMR1H NMRconcentrated sulfuric acidHMBC NMRHSQC NMRnucleobases

Identifiers

PMID41828832
PMCPMC12985984

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.