Conjugated Nitroolefins as Twofold Electrophiles for the Assembly of Five-Membered Monoheterocycles via MIRC [3+2] Annulation: An Update on Synthetic and Mechanistic Aspects.

Lara Bianchi, Massimo Maccagno, Giovanni Petrillo, Cinzia Tavani

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Review in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

4 authors.

Lara BianchiDepartment of Chemistry and Industrial Chemistry (DCCI), University of Genova, Via Dodecaneso 31, 16146 Genova, Italy.ORCID 0000-0001-8348-1361

Massimo MaccagnoDepartment of Chemistry and Industrial Chemistry (DCCI), University of Genova, Via Dodecaneso 31, 16146 Genova, Italy.ORCID 0000-0002-3149-4336

Giovanni PetrilloDepartment of Chemistry and Industrial Chemistry (DCCI), University of Genova, Via Dodecaneso 31, 16146 Genova, Italy.ORCID 0000-0002-8182-0144

Cinzia TavaniDepartment of Chemistry and Industrial Chemistry (DCCI), University of Genova, Via Dodecaneso 31, 16146 Genova, Italy.ORCID 0000-0003-4437-1121

Funding

University of Genova, Department of Chemistry and Indus- 789 trial Chemistry (DCCI) Impact Boosting 2022-100019

6 · The paper itself

Abstract

Five-membered monoheterocycles, either isolated or embedded in more complex systems, are ubiquitous structural motifs in nature and hence privileged targets of synthetic chemistry. Among a plethora of methodologies used for their assembly, [3+2] annulation strategies keep attracting particular interest among chemists, partly because of some significant characteristics from both the operative and the environmental viewpoints. Herein, the extensive use of conjugated nitroolefins as twofold electrophilic, two-carbon components of [3+2] MIRC (Michael-Initiated Ring Closure) annulations is reviewed as a practical and mechanistic update covering the last decade (2015-2025).

Indexed as

[3+2] annulationsfive-membered monoheterocyclesMichael-Initiated Ring Closure (MIRC)nitroolefins

Identifiers

PMID41828791

DOI10.3390/molecules31050803

PMCPMC12985949

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