Evidence map›Paper›PMID 41828718›Full record

ArticleInternational journal of molecular sciences2026

Prospective Monitoring of Serum Values of CBC, Total IgE, Thyroid Findings, D-Dimer, Vitamin D, and Inflammatory Molecules CRP, ESR, and IL-6 and Clinical Features of Chronic Spontaneous Urticaria Patients During Antihistamine Treatment.

Matea Kuna, Mario Štefanović, Ema Barac, Fran Ivan Madunić, Milena Hanžek, Liborija Lugović-Mihić

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Matea KunaDepartment of Dermatovenereology, University Hospital Center "Sestre Milosrdnice", Vinogradska 29, 10000 Zagreb, Croatia.ORCID 0000-0001-9932-5558
Mario ŠtefanovićDepartment of Clinical Chemistry, University Hospital Center "Sestre Milosrdnice", Vinogradska 29, 10000 Zagreb, Croatia.ORCID 0000-0002-3965-3231
Ema BaracDepartment of Dermatovenereology, University Hospital Center "Sestre Milosrdnice", Vinogradska 29, 10000 Zagreb, Croatia.
Fran Ivan MadunićDepartment of Oncology and Nuclear Medicine, University Hospital Center "Sestre Milosrdnice", Vinogradska 29, 10000 Zagreb, Croatia.
Milena HanžekDepartment of Clinical Chemistry, University Hospital Center "Sestre Milosrdnice", Vinogradska 29, 10000 Zagreb, Croatia.ORCID 0000-0003-3009-0599
Liborija Lugović-MihićDepartment of Dermatovenereology, University Hospital Center "Sestre Milosrdnice", Vinogradska 29, 10000 Zagreb, Croatia.ORCID 0000-0001-7494-5742

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Having appropriate and meaningful diagnostic procedures is crucial in the approach to patients with chronic spontaneous urticaria (CSU), so we wanted to investigate relationships between CSU patients' common serum factors and clinical CSU features, and their temporal trends during antihistamine treatment. In this exploratory hypothesis-based study, we assessed disease severity and quality of life (QoL) in, initially, 41 CSU patients using UAS7, daily UAS, UCT, DLQI, and CU-Q2oL. Concurrently, we measured serum complete blood count (CBC), total IgE, thyroid antibodies and hormones, ANA, D-dimer, vitamin D, and the inflammatory molecules CRP, ESR and IL-6. We compared initial (T1) and follow-up findings (T2) (after 3 months of antihistamine therapy). Basophil concentration was the only examined serum factor useful in assessing current CSU severity/daily UAS (sensitivity 78.6%; specificity 63%;

Indexed as

Chronic UrticariaHistamine AntagonistsImmunoglobulin EVitamin DAdultBiomarkersBlood Cell CountC-Reactive ProteinFemaleFibrin Fibrinogen Degradation ProductsHumansInterleukin-6MaleMiddle AgedProspective StudiesQuality of LifeBiomarkersC-Reactive ProteinFibrin Fibrinogen Degradation Productsfibrin fragment DHistamine AntagonistsImmunoglobulin EInterleukin-6Vitamin Dbiomarkersblood cell count (CBC)chronic spontaneous urticariaCRPD-dimerdiagnosticsESRIL-6quality of lifethyroid findingsvitamin D

Identifiers

PMID41828718
PMCPMC12985477

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.