Evidence map›Paper›PMID 41828715›Full record

ArticleInternational journal of molecular sciences2026

Engineering Epitope-Specific IgY Antibodies to Neutralize the Major Fel d 1 Allergen in Cats.

Xinya Tian, Chunxiao Li, Wei An, Yifei Wang, Zhenlong Wang, Jiaxue Wang, Xiaoxin Fu, Bing Han, Hui Tao, Christopher Jon Andrews and 2 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xinya TianKey Laboratory of Feed Biotechnology, Ministry of Agriculture and Rural Affairs, Beijing 100081, China.
Chunxiao LiKey Laboratory of Feed Biotechnology, Ministry of Agriculture and Rural Affairs, Beijing 100081, China.
Wei AnKey Laboratory of Feed Biotechnology, Ministry of Agriculture and Rural Affairs, Beijing 100081, China.
Yifei WangCollege of Animal Science & Technology, Nanjing Agricultural University, Nanjing 210095, China.
Zhenlong WangKey Laboratory of Feed Biotechnology, Ministry of Agriculture and Rural Affairs, Beijing 100081, China.ORCID 0009-0001-9889-2021
Jiaxue WangKey Laboratory of Feed Biotechnology, Ministry of Agriculture and Rural Affairs, Beijing 100081, China.
Xiaoxin FuKey Laboratory of Feed Biotechnology, Ministry of Agriculture and Rural Affairs, Beijing 100081, China.
Bing HanKey Laboratory of Feed Biotechnology, Ministry of Agriculture and Rural Affairs, Beijing 100081, China.ORCID 0009-0006-8457-9583
Hui TaoKey Laboratory of Feed Biotechnology, Ministry of Agriculture and Rural Affairs, Beijing 100081, China.
Christopher Jon AndrewsSchool of Agriculture and Environment, Massey University, Palmerston North 4410, New Zealand.ORCID 0000-0003-3049-1835
Jinquan WangKey Laboratory of Feed Biotechnology, Ministry of Agriculture and Rural Affairs, Beijing 100081, China.
Xiumin WangKey Laboratory of Feed Biotechnology, Ministry of Agriculture and Rural Affairs, Beijing 100081, China.ORCID 0000-0002-2008-856X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Approximately 10-24% of people suffer from a cat allergy. Fel d 1, the major allergen, triggers reactions in approximately 94% of sensitized individuals. Current therapeutic strategies for allergic diseases primarily involve medication or immunotherapy to alleviate symptoms, which are often burdened by low efficacy, high cost, and extended duration, posing significant challenges for patients. In contrast, IgY antibodies offer a promising alternative by reducing the level of allergens produced by cats. In this study, T-cell epitopes of Fel d 1 were predicted using ProPred/CTLpred, connected via a suitable linker (GGGGS), and expressed in

Indexed as

AllergensAntibodies, NeutralizingEpitopesEpitopes, T-LymphocyteGlycoproteinsImmunoglobulinsAnimalsCatsChickensFemaleHypersensitivityMiceRecombinant ProteinsAllergensAntibodies, NeutralizingEpitopesEpitopes, T-LymphocyteFel d 1 protein, Felis domesticusGlycoproteinsIgYImmunoglobulinsRecombinant ProteinsallergycFel d 1feline allergenIgY antibodyrecombinant expression

Identifiers

PMID41828715
PMCPMC12985922

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.