Evidence map›Paper›PMID 41828649›Full record

ArticleInternational journal of molecular sciences2026

miRNA 183 Knockout Alters Cone Subtype Distribution, Transcriptional Activity and ERG Signals in the Tetrachromatic Zebrafish Visual System.

Rongfang Chen, Gaohui Zhou, Xiaodong Jiao, Ralph F Nelson, Victoria P Connaughton, Lijin Dong, Brian D Perkins, J Fielding Hejtmancik

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Rongfang ChenOphthalmic Molecular Genetics Section, Ophthalmic Genetics and Visual Function Branch, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Gaohui ZhouOphthalmic Molecular Genetics Section, Ophthalmic Genetics and Visual Function Branch, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-6896-3132
Xiaodong JiaoOphthalmic Molecular Genetics Section, Ophthalmic Genetics and Visual Function Branch, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0009-0008-1040-1605
Ralph F NelsonNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Rockville, MD 20892, USA.ORCID 0000-0002-4179-7664
Victoria P ConnaughtonDepartment of Biology and Center for Neuroscience and Behavior, American University, Washington, DC 20016, USA.ORCID 0000-0001-6516-7299
Lijin DongVisual Function Core, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0001-7401-9511
Brian D PerkinsDepartment of Ophthalmic Research, Cole Eye Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
J Fielding HejtmancikOphthalmic Molecular Genetics Section, Ophthalmic Genetics and Visual Function Branch, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0009-0009-9144-7951

Funding

NEI NIH HHS ZIA EY000272-33
6 · The paper itself

Abstract

miRNA 183 is part of the miRNA-183/96/182 cluster, which is known to play a decisive role in fine-tuning the activity of gene expression in sensory systems, particularly in the retina. Although miR-183 is essential for retinal gene expression in mammals, the contributions of miR-183 to mRNA expression and photoreceptor development and function in other classes of animals have not been fully elucidated.

Indexed as

MicroRNAsRetinal Cone Photoreceptor CellsZebrafishAnimalsElectroretinographyGene Expression RegulationGene Knockout TechniquesRetinaMicroRNAsmiR-183photoreceptor-only ERG signalsshort-wavelength-sensitive photoreceptorsteleost fishzebrafish

Identifiers

PMID41828649
PMCPMC12985624

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.