Evidence map›Paper›PMID 41828627›Full record

Trial reportInternational journal of molecular sciences2026

The Usefulness of Metformin and Ganwei for Metabolic Dysfunction-Associated Steatotic Liver Disease: A Randomized, Placebo-Controlled Trial.

Chih-Lin Lin, Wei-You Li, Shang-Jung Wu, Patricia M T Chen, Allan Y Chen, Cathy Shen-Jang Fann, Yi-Ming Arthur Chen

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Chih-Lin LinDepartment of Gastroenterology, Ren-Ai Branch, Taipei City Hospital, Taipei 112, Taiwan.ORCID 0000-0002-9890-7596
Wei-You LiGraduate Institute of Biomedical and Pharmaceutical Science, College of Medicine, Fu Jen Catholic University, New Taipei City 242, Taiwan.ORCID 0000-0003-3182-3504
Shang-Jung WuInstitute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan.
Patricia M T ChenMedical Group, University of California Davis, Sacramento, CA 95816, USA.
Allan Y ChenCollege of Medicine, California Northstate University, Elk Grove, CA 95757, USA.
Cathy Shen-Jang FannInstitute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan.
Yi-Ming Arthur ChenGraduate Institute of Biomedical and Pharmaceutical Science, College of Medicine, Fu Jen Catholic University, New Taipei City 242, Taiwan.ORCID 0000-0002-6374-6905

Funding

Fu Jen Catholic University 913M332-01The One Biopharmaceutical Co., Ltd. NA
6 · The paper itself

Abstract

Metabolic dysfunction associated steatotic liver disease (MASLD), a globally prevalent chronic liver disease, has only limited pharmacological options. Both metformin and Ganwei, health supplements containing a potent inducer of glycine N-methyltransferase (GNMT), have shown great promise for the treatment of MASLD. We conducted a 4-arm, randomized, placebo-controlled trial to investigate the safety and efficacy of metformin and Ganwei for patients with MASLD. Between September 2021 and March 2023, 64 patients with MASLD were randomly assigned at a 1:1:1:1 ratio to receive metformin alone (arm A,

Indexed as

Drugs, Chinese HerbalFatty LiverMetforminNon-alcoholic Fatty Liver DiseaseAdultFemaleGlycine N-MethyltransferaseHumansMaleMiddle AgedPolymorphism, Single NucleotideTreatment OutcomeDrugs, Chinese HerbalGlycine N-MethyltransferaseMetforminGanweiGNMT inducerhealth supplementMASLDmetforminrs10948059

Identifiers

PMID41828627
PMCPMC12986483

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.