Evidence map›Paper›PMID 41828612›Full record

ReviewInternational journal of molecular sciences2026

Vitamin D Receptor Signaling and Ligand Modulation: Molecular Mechanisms and Therapeutic Implications.

Tram Thi-Ngoc Nguyen, Kouki Nojiri, Tomohiro Kurokawa, Takahiro Sawada, Yoshiaki Kanemoto, Shigeaki Kato

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Tram Thi-Ngoc NguyenDepartment of Pharmacy, Iryo Sosei University, Chuodai Iino, Iwaki 970-8551, Fukushima, Japan.
Kouki NojiriDepartment of Pharmacy, Iryo Sosei University, Chuodai Iino, Iwaki 970-8551, Fukushima, Japan.
Tomohiro KurokawaDepartment of Pharmacy, Iryo Sosei University, Chuodai Iino, Iwaki 970-8551, Fukushima, Japan.
Takahiro SawadaDepartment of Pharmacy, Iryo Sosei University, Chuodai Iino, Iwaki 970-8551, Fukushima, Japan.
Yoshiaki KanemotoDepartment of Pharmacy, Iryo Sosei University, Chuodai Iino, Iwaki 970-8551, Fukushima, Japan.
Shigeaki KatoDepartment of Pharmacy, Iryo Sosei University, Chuodai Iino, Iwaki 970-8551, Fukushima, Japan.ORCID 0000-0002-5564-1695

Funding

Japan Society for the Promotion of Science KAKENHI #23K15502the practical development projects by Fukushima prefecture N/ATokiwa Medical Foundation N/A
6 · The paper itself

Abstract

Vitamin D, a fat-soluble vitamin functioning as a hormone via the vitamin D receptor (VDR), is critical for calcium homeostasis and bone health. Vitamin D deficiency is linked to nutritional rickets, osteomalacia, and increased risk of non-communicable diseases such as cancer and diabetes. While serum 25(OH)D

Indexed as

Receptors, CalcitriolSignal TransductionAnimalsCalciumHumansLigandsVitamin DCalciumLigandsReceptors, CalcitriolVitamin Dhypercalcemiaselective VDR modulatorssynthetic analogsvitamin D receptor (VDR)

Identifiers

PMID41828612
PMCPMC12985309

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.