Evidence map›Paper›PMID 41828602›Full record

ArticleInternational journal of molecular sciences2026

A Two-Track Model of Huntington's Disease Pathology: Striatal Atrophy Mediates Maladaptive Immune Dysregulation.

H Jeremy Bockholt, Jordan D Clemsen, Bradley T Baker, Vince D Calhoun, Jane S Paulsen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

H Jeremy BockholtCenter for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Atlanta, GA 30303, USA.ORCID 0000-0001-8523-3361
Jordan D ClemsenCenter for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Atlanta, GA 30303, USA.
Bradley T BakerCenter for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Atlanta, GA 30303, USA.
Vince D CalhounCenter for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Atlanta, GA 30303, USA.
Jane S PaulsenDepartment of Neurology, University of Wisconsin-Madison, Madison, WI 53706, USA.ORCID 0000-0002-0983-228X

Funding

NEUROBIOLOGICAL PREDICTORS OF HUNTINGTON'S DISEASER01NS040068 · NINDS · UNIVERSITY OF IOWA · PI PAULSEN, JANE S · 2001 to 2013
$48.5M
Preparing for preventive clinical trials in Huntington's diseaseU01NS105509 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI PAULSEN, JANE S · 2020 to 2025
$2.5M
Statistical disease modeling and clinimetrics to prepare for preventive trials in huntington diseaseU01NS103475 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI PAULSEN, JANE S · 2020 to 2022
$1.7M
Preparing for preventive clinical trials in Huntington's diseaseR01NS105509 · NINDS · UNIVERSITY OF IOWA · PI PAULSEN, JANE S · 2018 to 2018
$658k
CHDI Foundation A3917CHDI Foundation A6266NIH/NINDS R01NS040068NIH/NINDS U01NS103475NIH/NINDS U01NS105509NINDS NIH HHS R01 NS105509NINDS NIH HHS U01 NS105509
6 · The paper itself

Abstract

Huntington's disease (HD) is characterized by progressive striatal atrophy and complex proteomic changes in the central nervous system. Using the ultrasensitive Next-Gen Ultra-Sensitive Immunoassay (NULISA) proteomic platform, we analyzed cerebrospinal fluid (CSF) from 88 persons with HD to dissect the biological correlates of gray matter loss. Our findings reveal a distinct "Two-Track" model of pathology. The first track, marked by the axonal damage protein neurofilament light chain (NEFL), showed a strong inverse correlation with putamen volume (Pearson

Indexed as

Corpus StriatumHuntington DiseaseAdultAgedAtrophyBiomarkersFemaleHumansMaleMiddle AgedNeurofilament ProteinsProteomicsPutamenBiomarkersneurofilament protein LNeurofilament ProteinsbiomarkersHuntington’s diseaseneurodegenerationneuro-immune axisneuroinflammationNULISAproteomicsstriatum

Identifiers

PMID41828602
PMCPMC12985888

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.