Evidence map›Paper›PMID 41828570›Full record

ArticleInternational journal of molecular sciences2026

The Plasma Glycome Differences Between Women with PCOS and Healthy Controls.

Madison Holman, Sophie Jie Li, Mary M Ahern, L Renee Ruhaak, Siddika Karakas, Sridevi Krishnan

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Madison HolmanDepartment of Ecology and Evolutionary Biology, School of Science, University of Arizona, Tucson, AZ 85721, USA.
Sophie Jie LiDepartment of Physiology, College of Medicine, University of Arizona, Tucson, AZ 85721, USA.ORCID 0009-0008-9103-5079
Mary M AhernSchool of Nutritional Sciences and Wellness, University of Arizona, Tucson, AZ 85721, USA.ORCID 0000-0002-0135-8712
L Renee RuhaakDepartment of Clinical Chemistry and Laboratory Medicine, Leiden University Medical Center, 2333 Leiden, The Netherlands.ORCID 0000-0003-3737-3807
Siddika KarakasDepartment of Medicine, University of California Davis, Sacramento, CA 95616, USA.
Sridevi KrishnanSchool of Nutritional Sciences and Wellness, University of Arizona, Tucson, AZ 85721, USA.

Funding

No funding to report NA
6 · The paper itself

Abstract

While PCOS research has extensively explored genomic, transcriptomic, proteomic, and metabolomic milieus, our study examines the plasma glycome, comparing women with PCOS to age-matched healthy controls. In this observational study, n = 47 women with PCOS were screened and enrolled at the UC Davis Health campus; the comparator group constituted of n = 25 age-matched healthy women. During a study visit, body weight and body composition were measured, and fasted plasma samples were obtained to measure glucose, insulin, circulating lipids, and leptin, among other parameters, in both groups. In addition, in the PCOS group, circulating androgens and other endocrine hormones were measured. The plasma glycome was measured using a UHPLC-MS protocol. As expected, women with PCOS had higher body weight (

Indexed as

Polycystic Ovary SyndromePolysaccharidesAdultBlood GlucoseCase-Control StudiesFemaleHumansInsulinLeptinBlood GlucoseInsulinLeptinPolysaccharidesglycomehybrid-type glycansPCOStestosteronetetraantennary glycans

Identifiers

PMID41828570
PMCPMC12985897

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.