ArticleInternational journal of molecular sciences2026
In Vitro Studies of the Effects of Antithrombotic Zn-Dipicolylamine-Harboring Liposomes (DPALs) on Serum Albumin and Human Umbilical Vein Endothelial Cells.
Michelle Tanujaya, Gianna Cai, Jia Patel, Zana Moldavsky, Yumna Ejaz, Malia Mahazabin Ahmed, SangSang Duong, Lawrence E Goldfinger, Koon Y Pak, Brian D Gray and 1 more
Abstract read
In one paragraphArticle in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
11 authors.
Michelle TanujayaDepartment of Medical Genetics and Molecular Biochemistry, The Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.ORCID 0009-0004-0032-6227 Gianna CaiDepartment of Medical Genetics and Molecular Biochemistry, The Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.
Jia PatelDepartment of Medical Genetics and Molecular Biochemistry, The Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.
Zana MoldavskyDepartment of Medical Genetics and Molecular Biochemistry, The Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.
Yumna EjazDepartment of Medical Genetics and Molecular Biochemistry, The Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.
Malia Mahazabin AhmedDepartment of Medical Genetics and Molecular Biochemistry, The Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.
SangSang DuongDepartment of Medical Genetics and Molecular Biochemistry, The Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.
Lawrence E GoldfingerCardeza Foundation for Hematologic Research, Department of Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA.ORCID 0000-0003-0525-6008 Brian D GrayMolecular Targeting Technologies Inc., West Chester, PA 19380, USA.
Parkson Lee-Gau ChongDepartment of Medical Genetics and Molecular Biochemistry, The Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.
Funding
Function and regulation of constitutive protein translation in plateletsR01HL159006 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI GOLDFINGER, LAWRENCE E · 2021 to 2024
$1.6MShort inhibitory RNAs in platelet and megakaryocyte functionR01HL172942 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI Lawrence E Goldfinger · 2025 to 2026
$1.1MPhosphatidylserine-blocking nanoparticles as improved anti-thrombotic with reduced bleeding riskR41HL167303 · NHLBI · MOLECULAR TARGETING TECHNOLOGIES, INC. · PI GRAY, BRIAN DAVID · 2023 to 2023
$300kNHLBI NIH HHS R01 HL159006NHLBI NIH HHS R01 HL172942NIH USA R41HL167303
6 · The paper itselfAbstract
Thrombosis remains a leading cause of cardiovascular morbidity and mortality. During thrombosis, activated platelets and endothelial cells expose phosphatidylserine (PS) on their outer membranes, creating a surface that accelerates clot formation. Current antithrombotic therapies, such as heparin and warfarin, carry significant bleeding risks, highlighting the need for safer alternatives. In response, we developed a PS-targeting liposomal formulation composed of Zn-dipicolylamine (DPA)-cyanine-3[22,22] and 1-palmitoyl-2-oleoyl-
Indexed as
AminesFibrinolytic AgentsHuman Umbilical Vein Endothelial CellsLiposomesPicolinic AcidsSerum AlbuminZincCell ProliferationHumans2,2'-dipicolylamineAminesFibrinolytic AgentsLiposomesPicolinic AcidsSerum AlbuminZincADIFAB assayantithrombotic agentcell proliferationcultured cellscytotoxicityintrinsic protein fluorescencenanoparticlesserum albuminsize and size distributiontranswell assay
Identifiers
PMID41828522
PMCPMC12985703
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