Evidence map›Paper›PMID 41828504›Full record

ArticleInternational journal of molecular sciences2026

The Clinical Significance of SPOP Upregulation and Nuclear Accumulation in Head and Neck Squamous Cell Carcinoma.

Yin-Hwa Shih, Nan-Chin Lin, Yen-Wen Shen, Ming-Gene Tu, Tong-Hong Wang, Yu-Hsin Tseng, Shih-Min Hsia, Tzong-Ming Shieh

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yin-Hwa ShihDepartment of Healthcare Administration, Asia University, Taichung 41354, Taiwan.ORCID 0000-0003-0893-4185
Nan-Chin LinDepartment of Oral and Maxillofacial Surgery, Show Chwan Memorial Hospital, Changhua 500, Taiwan.ORCID 0000-0002-2504-7708
Yen-Wen ShenSchool of Dentistry, China Medical University, Taichung 404328, Taiwan.
Ming-Gene TuSchool of Dentistry, China Medical University, Taichung 404328, Taiwan.
Tong-Hong WangTissue Bank, Chang Gung Memorial Hospital at Linkou, Taoyuan 33305, Taiwan.ORCID 0000-0001-9248-9031
Yu-Hsin TsengDepartment of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80756, Taiwan.ORCID 0000-0002-2558-2209
Shih-Min HsiaSchool of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei 110301, Taiwan.ORCID 0000-0003-2888-2618
Tzong-Ming ShiehSchool of Dentistry, China Medical University, Taichung 404328, Taiwan.ORCID 0000-0003-1759-9120

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The speckle-type BTB/POZ protein (SPOP) is an E3 ubiquitin ligase adaptor typically considered a tumor suppressor, yet its role in head and neck squamous cell carcinoma (HNSCC) remains unclear. This study investigated SPOP expression, arecoline regulation, and its potential as a HNSCC biomarker.

Indexed as

Carcinoma, Squamous CellCell NucleusHead and Neck NeoplasmsNuclear ProteinsRepressor ProteinsSquamous Cell Carcinoma of Head and NeckUp-RegulationArecolineBiomarkers, TumorCell Line, TumorFemaleGene Expression Regulation, NeoplasticHumansMaleRNA, MessengerArecolineBiomarkers, TumorNuclear ProteinsRepressor ProteinsRNA, MessengerSPOP protein, humanarecolinebiomarkerhead and neck squamous cell carcinoma (HNSCC)nuclear localizationSPOP

Identifiers

PMID41828504
PMCPMC12985595

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.