Evidence map›Paper›PMID 41828494›Full record

ArticleInternational journal of molecular sciences2026

Induced Sputum Multi-Omics Reveals Airway Signatures of COPD in Smokers: A Pilot Study.

Kaja Pulik, Piotr Korczyński, Katarzyna Mycroft-Rzeszotarska, Iga Ciesielska-Markowska, Magdalena Kucia, Magdalena Paplińska-Goryca, Diana Wierzbicka, Kannathasan Thetchinamoorthy, Zofia Wicik, Katarzyna Górska

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Plasma Lipidomic Signatures Across the Healthy-Pre-COPD-COPD Continuum Identified by Machine Learning.International journal of chronic obstructive pulmonary disease · 2026
    Observational
  3. Identifying Biomarkers for Chronic Obstructive Pulmonary Disease in the Salivary Metabolome.International journal of chronic obstructive pulmonary disease · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kaja PulikDepartment of Internal Medicine, Pulmonary Diseases and Allergy, Medical University of Warsaw, Banacha 1A, 02-097 Warsaw, Poland.ORCID 0000-0003-3724-1804
Piotr KorczyńskiDepartment of Pulmonary Diseases, Internal Medicine, Thoracic Oncology and Transplantology, National Medical Institute of the Ministry of Interior and Administration (MSWiA), Wołoska 137, 02-507 Warsaw, Poland.ORCID 0000-0003-2826-4430
Katarzyna Mycroft-RzeszotarskaDepartment of Internal Medicine, Pulmonary Diseases and Allergy, Medical University of Warsaw, Banacha 1A, 02-097 Warsaw, Poland.
Iga Ciesielska-MarkowskaDepartment of Internal Medicine, Pulmonary Diseases and Allergy, Medical University of Warsaw, Banacha 1A, 02-097 Warsaw, Poland.
Magdalena KuciaLaboratory of Regenerative Medicine, Medical University of Warsaw, Banacha 1B, 02-097 Warsaw, Poland.
Magdalena Paplińska-GorycaDepartment of Internal Medicine, Pulmonary Diseases and Allergy, Medical University of Warsaw, Banacha 1A, 02-097 Warsaw, Poland.ORCID 0000-0003-0576-7289
Diana WierzbickaLaboratory of Regenerative Medicine, Medical University of Warsaw, Banacha 1B, 02-097 Warsaw, Poland.
Kannathasan ThetchinamoorthyLaboratory of Regenerative Medicine, Medical University of Warsaw, Banacha 1B, 02-097 Warsaw, Poland.ORCID 0000-0002-4697-7330
Zofia WicikDepartment of Experimental and Clinical Pharmacology, Center for Preclinical Research and Technology CEPT, Medical University of Warsaw, 02-097 Warsaw, Poland.
Katarzyna GórskaDepartment of Pulmonary Diseases, Internal Medicine, Thoracic Oncology and Transplantology, National Medical Institute of the Ministry of Interior and Administration (MSWiA), Wołoska 137, 02-507 Warsaw, Poland.ORCID 0000-0003-4686-910X

Funding

National Science Centre UMO-2019/35/B/NZ5/00694
6 · The paper itself

Abstract

Chronic obstructive pulmonary disease (COPD) is a leading cause of mortality worldwide, yet only a fraction of smokers develops the disease, suggesting protective mechanisms in resilient individuals. Identifying airway-localized molecular signatures may improve our understanding of disease pathomechanisms and support hypothesis generation for biomarker research. In this pilot study, induced sputum from smokers with COPD (

Indexed as

Pulmonary Disease, Chronic ObstructiveSmokingSputumAgedBiomarkersFemaleHumansMaleMetabolomicsMiddle AgedMultiomicsPilot ProjectsProteomicsSmokersBiomarkersCOPDinduced sputumlipidomicsmetabolomicsmulti-omicspathway enrichmentproteomics

Identifiers

PMID41828494
PMCPMC12984585

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.