Evidence map›Paper›PMID 41828456›Full record

ArticleInternational journal of molecular sciences2026

Inflammasome Activation by Neutrophil Extracellular Traps (NETs) in the MDA-MB-231 Human Breast Cancer Cell Line.

Alexander Gonçalves da Silva, Evellyn Pereira, Vitor H Almeida, Laryssa D Pinto, Juliana L Souza, Tatiana M Tilli, Robson Coutinho-Silva, Emiliano Medei, Sandra Konig, Robson Q Monteiro

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Alexander Gonçalves da SilvaInstitute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Rio de Janeiro 21590-902, Brazil.
Evellyn PereiraInstitute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Rio de Janeiro 21590-902, Brazil.
Vitor H AlmeidaInstitute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Rio de Janeiro 21590-902, Brazil.ORCID 0000-0002-2789-7116
Laryssa D PintoInstitute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Rio de Janeiro 21590-902, Brazil.
Juliana L SouzaInstitute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Rio de Janeiro 21590-902, Brazil.
Tatiana M TilliCenter for Technological Development in Health, Oswaldo Cruz Foundation, Rio de Janeiro 21040-900, Brazil.ORCID 0000-0002-1111-018X
Robson Coutinho-SilvaInstitute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro 21941-590, Brazil.ORCID 0000-0002-7318-0204
Emiliano MedeiInstitute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro 21941-590, Brazil.ORCID 0000-0002-0044-1311
Sandra KonigInstitute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio de Janeiro 21941-902, Brazil.
Robson Q MonteiroInstitute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Rio de Janeiro 21590-902, Brazil.ORCID 0000-0002-5260-2332

Funding

Coordination for the Improvement of Higher Education Personnel (CAPES) 23038.009431/2021-42National Council for Scientific and Technological Development 306698/2022-6The State of Rio de Janeiro Research Foundation (FAPERJ) E-26/201.093/2022The State of Rio de Janeiro Research Foundation (FAPERJ) E-26/211.277/2021
6 · The paper itself

Abstract

Inflammation is a key feature in breast cancer progression, with neutrophil extracellular traps (NETs) playing an important role. NETs are DNA-based structures released by neutrophils that can promote tumor adhesion, invasion, and immune evasion. Another crucial mechanism is the inflammasome, a multiprotein complex that drives inflammation through cytokine release. Both mechanisms are present in tumors and may act synergistically. In this study, we evaluated how isolated NETs modulate the NLRP3 inflammasome in a human breast cancer model. Exposure of MDA-MB-231 cells to NETs increased the expression of

Indexed as

Breast NeoplasmsExtracellular TrapsInflammasomesNeutrophilsCaspase 1Cell Line, TumorCell MovementFemaleHumansInterleukin-1betaMDA-MB-231 CellsNLR Family, Pyrin Domain-Containing 3 ProteinCaspase 1InflammasomesInterleukin-1betaNLR Family, Pyrin Domain-Containing 3 ProteinNLRP3 protein, humanbreast cancerinflammasomeInterleukin-1neutrophil extracellular traps

Identifiers

PMID41828456
PMCPMC12985087

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.