JNJ-26366821 Attenuates Radiation-Induced Pro-Inflammatory Cytokines and miRNAs and Triggers TR/RXR Signaling Pathway.

Vidya P Kumar, Bernedette Hritzo, Dharmendra Kumar Soni, Venkateshwara Rao Dronamraju, Gregory P Holmes-Hampton, Roopa Biswas, Sanchita P Ghosh

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Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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5 · Who and what money

Authors and funding

7 authors.

Vidya P KumarArmed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD 20889, USA.ORCID 0000-0002-6321-7640

Bernedette HritzoArmed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD 20889, USA.

Dharmendra Kumar SoniDepartment of Anatomy, Physiology and Genetics, School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20889, USA.ORCID 0000-0002-7702-6546

Venkateshwara Rao DronamrajuArmed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD 20889, USA.

Gregory P Holmes-HamptonArmed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD 20889, USA.

Roopa BiswasDepartment of Anatomy, Physiology and Genetics, School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20889, USA.ORCID 0000-0003-1400-6692

Sanchita P GhoshArmed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD 20889, USA.ORCID 0000-0002-0261-460X

Funding

CDMRP and the AFRRI Intramural funding JPC-7 project DM178020, and the AFRRI Intramural funding RAB23338

6 · The paper itself

Abstract

JNJ-26366821, a novel thrombopoietin mimetic peptide (TPOm), is shown to increase platelets (PLTs) transiently in peripheral blood. We hypothesized that increases in PLT counts may involve stimulation of hematopoiesis via induction of cytokines, growth factors, and microRNAs. Hence, we measured various cytokines, chemokines, and growth factors in serum. Time-course analysis of G-CSF, IL-5, IL-6, IL-9, IL-10, TNFα, IL-1α, and IL-1β expression was significantly altered in the control group at 9.5 Gy compared to a lower non-lethal dose of 7 Gy on days 7 to 15 post-exposure. TPOm pre-treatment significantly ameliorated the changes in expression of these pro-inflammatory cytokines and growth factors. Additionally, we show that TPOm differentially modulates the miRNA expression profiles in the spleen of irradiated mice compared to controls at both early times as well as later times after irradiation. These results suggest a possible role of TPOm in protecting animals from radiation-induced thrombocytopenia and lethality by attenuating radiation-induced inflammatory cytokines and miRNAs.

Indexed as

CytokinesMicroRNAsSignal TransductionThrombopoietinAnimalsGene Expression RegulationMaleMiceSpleenCytokinesMicroRNAsThrombopoietinH-ARSmiRNAspro-inflammatory cytokinessignaling pathwaythrombopoietin mimetic peptidetotal body irradiationTPOm

Identifiers

PMID41828408

DOI10.3390/ijms27052181

PMCPMC12984971

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