Evidence map›Paper›PMID 41828367›Full record

ArticleInternational journal of molecular sciences2026

UV-Crosslinked Collagen and Gelatin Sheets as Cell Scaffold Materials: Nanoscale Surface Properties and Cell Proliferation Performance.

Seima Ishikawa, Keita Haraguchi, Sayaka Masaike, Toshiaki Takezawa, Shigehisa Aoki, Takayuki Narita

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Seima IshikawaDepartment of Chemistry and Applied Chemistry, Saga University, Saga 840-8502, Japan.
Keita HaraguchiDepartment of Chemistry and Applied Chemistry, Saga University, Saga 840-8502, Japan.
Sayaka MasaikeDepartment of Chemistry and Applied Chemistry, Saga University, Saga 840-8502, Japan.
Toshiaki TakezawaFaculty of Pharmacy, Chiba Institute of Science, Chiba 288-0025, Japan.ORCID 0000-0002-1825-838X
Shigehisa AokiDepartment of Pathology and Microbiology, Saga University, Saga 849-8501, Japan.ORCID 0000-0002-1778-8944
Takayuki NaritaDepartment of Chemistry and Applied Chemistry, Saga University, Saga 840-8502, Japan.ORCID 0000-0003-4082-9043

Funding

Japan Agency for Medical Research and Development 24ym0126816j0003Japan Society for the Promotion of Science 22K12821JKA Foundation 2025M-558
6 · The paper itself

Abstract

Collagen and gelatin are promising cell scaffold materials, but their structural instability under physiological conditions necessitates crosslinking treatment. This study evaluated UV crosslinking (254 nm, 0-180 min) as a non-toxic alternative to chemical crosslinking for collagen sheets (CS) and gelatin sheets (GS). Physicochemical properties were characterized by gel fraction analysis, atomic force microscopy (AFM) in PBS, and Fourier transform infrared spectroscopy (FT-IR), while NIH-3T3 fibroblast proliferation was evaluated by CCK-8 assay. UV crosslinking dramatically improved GS water resistance (gel fraction increased from 22% to 80% at 60 min) while maintaining smooth nanoscale surfaces (

Indexed as

Biocompatible MaterialsCollagenGelatinTissue ScaffoldsUltraviolet RaysAnimalsCell ProliferationCross-Linking ReagentsElastic ModulusMiceMicroscopy, Atomic ForceNIH 3T3 CellsSpectroscopy, Fourier Transform InfraredSurface PropertiesTissue EngineeringBiocompatible MaterialsCollagenCross-Linking ReagentsGelatincell adhesioncollagenelastic modulusgelatinsurface roughnesstissue engineeringUV crosslinking

Identifiers

PMID41828367
PMCPMC12984521

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.