ArticleInternational journal of molecular sciences2026
Pubertal Development Following Paediatric Gonadotoxic Treatment and Immature Testicular Tissue Banking.
Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Fertility preservation in prepubertal boys: management and follow-up challenges.Endocrine connections · 2026Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Paediatric gonadotoxic treatments can compromise male fertility, yet prospective data systematically tracking pubertal development are scarce. Immature testicular tissue banking (TTB) has been introduced as an experimental fertility preservation option for (pre-)pubertal boys, but its long-term safety and interaction with gonadotoxic treatment are not fully understood. This single-centre prospective cohort study systematically followed 23 boys, treated for malignant or non-malignant conditions, between 2017 and 2025 [median 4.0 (0.1-6.9) years], including 15 who underwent TTB. Unlike previous studies, this research combined repeated assessments of pubertal staging, testicular volumes, parenchymal integrity, reproductive hormones, and bone age and density, enabling a multidimensional evaluation of pubertal development. Gonadotoxic treatments, particularly myeloablative conditioning, were associated with reduced post-pubertal testicular volumes and altered hormone profiles, including elevated luteinising hormone and follicle-stimulating hormone, and reduced inhibin B, while anti-Müllerian hormone remained largely stable. Puberty occurred spontaneously and testosterone production was preserved in all patients. The testicular parenchyma appeared unaffected by the biopsy, and although some biopsied testes showed lower volumes, similar reductions could be observed in non-biopsied testes. These results support the safety of TTB, with no evident adverse effects on testicular structure or function; however, larger multicentric prospective studies are needed to confirm these findings.
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Registered trials
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