Evidence map›Paper›PMID 41828362›Full record

ReviewInternational journal of molecular sciences2026

Genetic Mutations and Non-Genomic Dysregulation in Human Preimplantation Embryo Arrest.

Jianan Jiang, Junhua Peng, Lin Li, Min Xu

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jianan JiangGuangdong Provincial Key Laboratory of Proteomics, Department of Pathophysiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China.ORCID 0009-0004-2688-0453
Junhua PengObstetrics and Gynecology Center, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China.ORCID 0000-0002-1590-2600
Lin LiGuangdong Provincial Key Laboratory of Proteomics, Department of Pathophysiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China.
Min XuDepartment of Cell Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China.

Funding

National Key R&D Program of China 2021YFA1102700National Natural Science Foundation of China 32570949, 82101745 and 32070833
6 · The paper itself

Abstract

Human preimplantation embryo arrest (PREMBA) represents a significant clinical hurdle in assisted reproductive technology (ART), in which approximately 10% of in vitro fertilized (IVF) embryos arrest at the cleavage stages. Whole-exome sequencing (WES) studies have discovered numerous genetic mutations associated with preimplantation embryo arrest. These mutations often disrupt critical biological milestones such as maternal mRNA clearance (

Indexed as

BlastocystEmbryonic DevelopmentMutationFemaleGene Expression Regulation, DevelopmentalHumansepigenetic reprogrammingmaternal-to-zygotic transition (MZT)preimplantation embryo arrest (PREMBA)zygotic genome activation (ZGA)

Identifiers

PMID41828362
PMCPMC12984818

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.