ArticleInternational journal of molecular sciences2026
Combined and Separate Pretreatments with L-Theanine and Aerobic Exercise Modulate Cognitive Decline Following Chronic Neuroinflammation in Rats Exposed to Lipopolysaccharide.
Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Chronic neuroinflammation is a prominent feature of several central nervous system disorders and contributes significantly to cognitive impairment. The present study aimed to investigate the effects of pretreatment with L-theanine (LT), aerobic exercise (ex), and their combination on cognitive deficits induced by subchronic lipopolysaccharide (LPS) administration in rats. Male Wistar rats were assigned to the following groups: control; veh-sed-LPS, sedentary (sed) rats treated with vehicle (veh) and LPS; LT-sed-LPS; veh-ex-LPS; and LT-ex-LPS. L-theanine treatment and/or treadmill running were administered for 5 weeks. Following these interventions, neuroinflammation was induced by LPS injections for 7 days, while the control group received veh treatment. Cognitive function was assessed using Y-maze, object recognition, and object location tests. Hippocampal cAMP response element-binding protein (CREB) phosphorylation status, β-amyloid (Aβ
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