Evidence map›Paper›PMID 41828343›Full record

ArticleInternational journal of molecular sciences2026

Role of Piezo1 Channels Expressed in PVN in Regulating Sympathetic Nerve Activity and Arterial Blood Pressure in Rats.

Yue Chen, Wei Guo, Jichun Wang, Min Wang, Yuying Yang, Gregory J Miodonski, Enshe Jiang, Qing-Hui Chen, Yi Yang, Renjun Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yue ChenDepartment of Biotechnology, School of Life Science, Jilin Normal University, Siping 136000, China.
Wei GuoCollege of Life Sciences, Dezhou University, Dezhou 253023, China.
Jichun WangDepartment of Biotechnology, School of Life Science, Jilin Normal University, Siping 136000, China.
Min WangDepartment of Biotechnology, School of Life Science, Jilin Normal University, Siping 136000, China.
Yuying YangDepartment of Biotechnology, School of Life Science, Jilin Normal University, Siping 136000, China.
Gregory J MiodonskiDepartment of Kinesiology and Integrative Physiology, Michigan Technological University, Houghton, MI 49931-1200, USA.ORCID 0009-0008-8816-1410
Enshe JiangSchool of Nursing and Health, Institutes of Nursing and Health, Henan University, Kaifeng 450046, China.ORCID 0000-0003-1344-5431
Qing-Hui ChenDepartment of Kinesiology and Integrative Physiology, Michigan Technological University, Houghton, MI 49931-1200, USA.ORCID 0000-0002-1639-5292
Yi YangDepartment of Biotechnology, School of Life Science, Jilin Normal University, Siping 136000, China.ORCID 0000-0003-2685-2722
Renjun WangDepartment of Biotechnology, School of Life Science, Jilin Normal University, Siping 136000, China.ORCID 0000-0003-0058-6219

Funding

the Program for th Development of Science and Technology of Jilin Province YDZJ202201ZYTS457
6 · The paper itself

Abstract

Mechanosensitive Piezo1 channels participate in regulating pain sensitivity, insulin secretion, and vascular tension; however, their expression in the autonomic paraventricular nucleus (PVN) and role in modulating sympathetic outflow and cardiovascular function remain unstudied. In this study, unilateral PVN microinjection of the Piezo1 channel blocker Dooku1 (0.1, 1, 10, 100, and 200 pmol) administered to anesthetized male rats increased renal sympathetic nerve activity (RSNA) and mean artery pressure (MAP) in a dose-dependent manner, with maximum increases of 93 ± 30% (

Indexed as

Arterial PressureIon ChannelsParaventricular Hypothalamic NucleusSympathetic Nervous SystemAnimalsBlood PressureIntercellular Signaling Peptides and ProteinsMaleRatsRats, Sprague-DawleySpider VenomsIntercellular Signaling Peptides and ProteinsIon ChannelsMTx4 protein, Grammostola spatulataPiezo1 protein, ratSpider Venomsarterial blood pressureCa2+-activated K+ channelsparaventricular nucleusPiezo1sympathetic nerve activity

Identifiers

PMID41828343
PMCPMC12984500

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.