Evidence map›Paper›PMID 41828341›Full record

ArticleInternational journal of molecular sciences2026

Cellular Anti-Apoptotic Effects of Dapagliflozin in Methotrexate-Induced Liver Toxicity: Bax/Bcl-2/Cyt-C/Cas-9/Cas-3 Signaling Pathway.

Emine Sarman, Halil Asci

Erratum issuedAbstract read
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In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Emine SarmanDepartment of Histology and Embryology, Faculty of Medicine, Afyonkarahisar Health Sciences University, Afyonkarahisar 03030, Türkiye.ORCID 0000-0002-4671-9315
Halil AsciDepartment of Pharmacology, Faculty of Medicine, Suleyman Demirel University, Isparta 32260, Türkiye.ORCID 0000-0002-1545-035X

Funding

Afyonkarahisar Health Sciences University Scientific Research Project Unit (AFSU-BAP) provided financial support for the study 24. GENEL.031
6 · The paper itself

Abstract

Methotrexate (MTX), an effective immunosuppressive and antiproliferative agent, is clinically restricted by its hepatotoxic potential through oxidative stress, inflammation, and apoptosis. Dapagliflozin (DAPA), a sodium-glucose cotransporter 2 inhibitor, exhibits antioxidant and anti-inflammatory actions. This study investigated the hepatoprotective effects of DAPA against MTX-induced acute liver injury. Thirty-two female Wistar albino rats were divided into four groups (

Indexed as

ApoptosisBenzhydryl CompoundsChemical and Drug Induced Liver InjuryGlucosidesMethotrexateSignal TransductionAnimalsbcl-2-Associated X ProteinCaspase 3Caspase 9FemaleLiverOxidative StressProto-Oncogene Proteins c-bcl-2RatsRats, Wistarbcl-2-Associated X ProteinBcl2 protein, ratBenzhydryl CompoundsCaspase 3Caspase 9dapagliflozinGlucosidesMethotrexateProto-Oncogene Proteins c-bcl-2acute liver injuryapoptosisNF-κBsodium–glucose cotransporter 2 inhibitorVEGF

Identifiers

PMID41828341
PMCPMC12984853

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.