Evidence map›Paper›PMID 41828317›Full record

ArticleInternational journal of molecular sciences2026

Toward Understanding the Role of miRNAs in Cleft Palate Only: Observations from Patient Tissues and In Vitro Assays.

Annalisa Palmieri, Luca Scapoli, Agnese Pellati, Federico Apolloni, Valerio Zanchi, Giuseppe Spinelli, Rossella Sgarzani, Francesco Carinci, Marcella Martinelli

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Annalisa PalmieriDepartment of Medical and Surgical Sciences, University of Bologna, 40126 Bologna, Italy.ORCID 0000-0001-6338-7394
Luca ScapoliDepartment of Medical and Surgical Sciences, University of Bologna, 40126 Bologna, Italy.ORCID 0000-0003-4006-9910
Agnese PellatiDepartment of Translational Medicine and for Romagna, University of Ferrara, 44121 Ferrara, Italy.
Federico ApolloniRegional Center for Diagnosis and Treatment of Cranio-Maxillofacial Malformation, Maxillofacial Unit, Ospedale San Bortolo, 36100 Vicenza, Italy.ORCID 0000-0002-1991-4115
Valerio ZanchiDepartment of Neurosurgery, Meyer Children's Hospital IRCCS, 50139 Florence, Italy.ORCID 0009-0001-5697-8599
Giuseppe SpinelliMaxillo-Facial Unit, Azienda Ospedaliero Universitaria Careggi, 50134 Florence, Italy.ORCID 0000-0003-3834-0433
Rossella SgarzaniDepartment of Medical and Surgical Sciences, University of Bologna, 40126 Bologna, Italy.ORCID 0000-0002-5543-8013
Francesco CarinciDepartment of Translational Medicine and for Romagna, University of Ferrara, 44121 Ferrara, Italy.ORCID 0000-0001-9639-6676
Marcella MartinelliDepartment of Medical and Surgical Sciences, University of Bologna, 40126 Bologna, Italy.ORCID 0000-0003-0219-7890

Funding

Banca d'ItaliaBENEFICENTIA StiftungInterethnos-Interplast Italy
6 · The paper itself

Abstract

Cleft palate only (CPO) is a multifactorial craniofacial malformation with significant genetic and epigenetic contributions. Among these, microRNAs (miRNAs) have emerged as key regulators of palate development, although their alterations in CPO remain incompletely characterized. In this study, we performed a comprehensive miRNA expression analysis on palatal tissues from an Italian cohort of non-syndromic CPO patients, compared with a human embryonic palatal mesenchymal (HEPM) cell line. Using the NanoString

Indexed as

Cleft PalateMicroRNAsCell LineFemaleGene Expression ProfilingGene Expression Regulation, DevelopmentalHumansMalePalatePAX9 Transcription FactorMicroRNAsMIR205, humanMIRN125 microRNA, humanMIRN200 microRNA, humanPAX9 protein, humanPAX9 Transcription Factorcleft palate onlycraniofacial developmentgene expressionmicroRNAspalatogenesis

Identifiers

PMID41828317
PMCPMC12985306

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.