Evidence map›Paper›PMID 41827915›Full record

ArticleCells2026

The Role of Pancreatic Preproglucagon in Regulating Local Inflammation in Mice.

Ellen M Zalucha, Chelsea R Hutch, Maigen Bethea, Tyler M Cook, Aayush Unadkat, Kristen L Wells, Ki-Suk Kim, Basma Maerz, Michael Lehrke, Kanakadurga Singer and 1 more

Abstract read
In one paragraph

Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ellen M ZaluchaDepartment of Nutritional Sciences, University of Michigan, Ann Arbor, MI 48109, USA.
Chelsea R HutchDepartment of Surgery, University of Michigan, Ann Arbor, MI 48109, USA.
Maigen BetheaDepartment of Pediatrics, Section of Nutrition, University of Colorado Anschutz, Medical Campus, Aurora, CO 80045, USA.
Tyler M CookDepartment of Pediatrics, Section of Nutrition, University of Colorado Anschutz, Medical Campus, Aurora, CO 80045, USA.
Aayush UnadkatDepartment of Surgery, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0009-0009-7126-9203
Kristen L WellsBarbara Davis Center for Diabetes, University of Colorado School of Medicine, Aurora, CO 80045, USA.ORCID 0000-0002-7466-8164
Ki-Suk KimDepartment of Surgery, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0001-8673-7377
Basma MaerzDepartment of Surgery, University of Michigan, Ann Arbor, MI 48109, USA.
Michael LehrkeDepartment of Internal Medicine I-Cardiology, University Hospital Aachen, Pauwelsstraße 30, 52074 Aachen, Germany.
Kanakadurga SingerDepartment of Pediatric Endocrinology, University of Michigan, Ann Arbor, MI 48105, USA.ORCID 0000-0001-8278-3800
Darleen A SandovalDepartment of Pediatrics, Section of Nutrition, University of Colorado Anschutz, Medical Campus, Aurora, CO 80045, USA.ORCID 0000-0003-3669-3278

Funding

Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3M
NIDDK National Research Service Award (NRSA) T32 Diversity Administrative SupplementT32DK007658 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Kristen Elizabeth Boyle, Ihuoma U Eneli · 1991 to 2026
$6.0M
Mechanisms of Post-Bariatric HypoglycemiaR01DK121995 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PATTI, MARY E, SANDOVAL, DARLEEN A. · 2019 to 2022
$2.8M
The Colorado Building Interdisciplinary Research Careers in Women's Health ProgramK12AR084226 · NIAMS · UNIVERSITY OF COLORADO DENVER · PI JUDITH G. REGENSTEINER, Nanette F. Santoro · 2023 to 2026
$2.5M
A novel paracrine role for GLP-1 in the isletR01DK107282 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SANDOVAL, DARLEEN A. · 2017 to 2020
$1.6M
Training for minoritized individuals in gut-brain axis researchK26DK138368 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI DARLEEN A. SANDOVAL · 2023 to 2026
$461k
Creating learning communities in support of diabetes and metabolism researchK26DK138307 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Kanakadurga Singer · 2023 to 2026
$314k
The role of diminished CNS hypoglycemia sensing in postbariatric hypoglycemiaF32DK139710 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Tyler Cook · 2024 to 2026
$151k
American Diabetes Association 1-19-IBS-252Burroughs Wellcome Fund N/ANIDDK NIH HHS K26 DK138307NIDDK NIH HHS P30 DK020572NIH Common Fund F32DK139710NIH Common Fund K12AR084226NIH Common Fund K26DK138368NIH Common Fund L70DK144920NIH Common Fund P30DK048250NIH Common Fund R01DK107282NIH Common Fund R01DK121995NIH Common Fund T32DK007658
6 · The paper itself

Abstract

Data suggest that both pancreatic and intestinally produced glucagon-like peptide-1 (GLP-1) increases in response to inflammation. Here, we set out to determine the tissue-specific function of increased GLP-1 during inflammatory stimuli. Using our innovative mouse model of tissue-specific

Indexed as

InflammationPancreasProglucagonAnimalsCytokinesDiet, High-FatGlucagon-Like Peptide 1Glucagon-Like Peptide-1 ReceptorLipopolysaccharidesMacrophagesMaleMiceMice, Inbred C57BLCytokinesGlucagon-Like Peptide 1Glucagon-Like Peptide-1 ReceptorLipopolysaccharidesProglucagonGLP-1inflammationpancreaspreproglucagon

Identifiers

PMID41827915
PMCPMC12985211

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.