Evidence map›Paper›PMID 41827896›Full record

ReviewCells2026

MG53 in Early Skeletal Muscle Stem Cell Activation: Implications for Aged Muscle Regeneration.

Yanping Xu, Jethro Wang Zih-Shuo, Zhentao Zhang, Peng Chen, Usman Alizai, Keerthika Sathish, Sakai Lilian, Zhiyu Yan, Bryan A Whitson, Timothy M Pawlik and 1 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yanping XuDepartment of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.ORCID 0000-0002-8537-5105
Jethro Wang Zih-ShuoDepartment of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.ORCID 0009-0004-0277-1818
Zhentao ZhangDepartment of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.ORCID 0000-0002-7260-1281
Peng ChenDepartment of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.
Usman AlizaiDepartment of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.
Keerthika SathishDepartment of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.
Sakai LilianDepartment of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.
Zhiyu YanDepartment of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.
Bryan A WhitsonDepartment of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.
Timothy M PawlikDepartment of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.ORCID 0000-0002-7994-9870
Hua ZhuDepartment of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.ORCID 0000-0001-7136-7326

Funding

MG53 function in muscle agingR01AG071676 · NIA · UNIVERSITY OF VIRGINIA · PI Jianjie Ma, Ki Ho Park · 2022 to 2026
$3.1M
Regulation of Mitsugumin 29 expression in muscle physiology and diseasesR01AR067766 · NIAMS · OHIO STATE UNIVERSITY · PI ZHU, HUA · 2016 to 2020
$1.6M
Inhibiting Cell Death for Protecting Cardiac InjuryR01HL153876 · NHLBI · OHIO STATE UNIVERSITY · PI ZHU, HUA · 2020 to 2023
$1.6M
AHA Postdoctoral Fellowship 26POST1571259American Heart Association 23TPA1142638NHLBI NIH HHS R01 HL153876NIAMS NIH HHS R01 AR067766NIA NIH HHS R01 AG071676NIH Common Fund AG071676NIH Common Fund AR067766NIH Common Fund HL153876
6 · The paper itself

Abstract

Skeletal muscle regeneration declines with age despite the persistence of satellite cells (muscle stem cells, MuSCs), suggesting that regenerative impairment reflects functional dysregulation rather than MuSC depletion. Increasing evidence identifies early MuSC activation during the immediate post-injury period as a stress-sensitive, rate-limiting transition that is particularly vulnerable in aged muscle. Aged MuSCs exhibit elevated stress responses and reduced membrane remodeling capacity, accompanied by weakened activation-associated transcriptional induction. In contrast, proliferative and differentiation programs remain largely intact once activation is successfully initiated. These findings underscore that impaired coordination during early activation contributes to long-term regenerative decline in aging. Within this framework, MG53 (tripartite motif-containing protein 72,

Indexed as

AgingMuscle, SkeletalRegenerationSatellite Cells, Skeletal MuscleStem CellsAnimalsCell DifferentiationHumansTripartite Motif ProteinsTRIM72 protein, humanTripartite Motif Proteinsactivation checkpointagingMG53/TRIM72satellite cell activationskeletal muscle regenerationstress

Identifiers

PMID41827896
PMCPMC12984147

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.