Evidence map›Paper›PMID 41827887›Full record

ArticleCells2026

Caffeic Acid Derivative MPMCA Inhibits Prostate Cancer EMT and Metastasis by Regulating Transcription Factors Snail and Slug.

Jo-Yu Lin, Tien-Huang Lin, Yuan-Li Huang, Chao-Yang Lai, Trung-Loc Ho, Chun-Hao Tsai, Yi-Chin Fong, Hsi-Chin Wu, An-Chen Chang, Yueh-Hsiung Kuo and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Potential impact ofInternational journal of medical sciences · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jo-Yu LinGraduate Institute of Biomedical Sciences, China Medical University, Taichung 404333, Taiwan.
Tien-Huang LinSchool of Post-Baccalaureate Chinese Medicine, Tzu Chi University, Hualien 970374, Taiwan.
Yuan-Li HuangDepartment of Medical Laboratory Science and Biotechnology, Asia University, Taichung 413305, Taiwan.ORCID 0000-0002-3405-8863
Chao-Yang LaiDepartment of Medical Laboratory Science and Biotechnology, Asia University, Taichung 413305, Taiwan.
Trung-Loc HoGraduate Institute of Biomedical Sciences, China Medical University, Taichung 404333, Taiwan.ORCID 0000-0001-9565-8419
Chun-Hao TsaiDepartment of Sports Medicine, College of Health Care, China Medical University, Taichung 404333, Taiwan.ORCID 0000-0002-4428-3132
Yi-Chin FongDepartment of Sports Medicine, College of Health Care, China Medical University, Taichung 404333, Taiwan.
Hsi-Chin WuSchool of Medicine, China Medical University, Taichung 404333, Taiwan.
An-Chen ChangSchool of Oral Hygiene, College of Oral Medicine, Taipei Medical University, Taipei City 110301, Taiwan.
Yueh-Hsiung KuoDepartment of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 404333, Taiwan.ORCID 0000-0001-5935-6755
Sung-Lin HuSchool of Medicine, China Medical University, Taichung 404333, Taiwan.
Chih-Hsin TangGraduate Institute of Biomedical Sciences, China Medical University, Taichung 404333, Taiwan.ORCID 0000-0002-7113-8352

Funding

National Science and Technology Council (NSTC), Taiwan NSTC 113-2314-B-715-009National Science and Technology Council (NSTC), Taiwan NSTC 113-2320-B-039-049-MY3
6 · The paper itself

Abstract

Prostate cancer (PCa) is the most general cancer in men and is often linked with distant metastasis in its later stages. The caffeic acid (CA) derivative, N-(4-methoxyphenyl)methylcaffeamide (MPMCA), demonstrates superior liver-protective effects compared to CA. Nevertheless, the functions of MPMCA on prostate cancer metastasis remain unclear. Here, we demonstrate that MPMCA blocks migration and invasion in prostate cancer cells without affecting cell viability. By suppressing the production of mesenchymal markers Vimentin, N-cadherin and β-catenin and upregulating the production of the epithelial marker Zonula Occludens-1 (ZO-1), MPMCA also controls Epithelial-Mesenchymal Transition (EMT). The Phosphoinositide 3-kinase (PI3K), Protein kinase B (AKT) and mechanistic target of rapamycin (mTOR) pathway has been documented to regulate MPMCA-inhibited cell motility. Transfection with Snail and Slug cDNA reverses MPMCA's suppression of EMT, migration, and invasion in prostate cancer cells. Importantly, our in vivo data indicates that MPMCA reduces Snail and Slug expression and prostate cancer metastasis. Our evidence suggests that MPMCA is a novel therapeutic candidate for treating metastatic prostate cancer.

Indexed as

Caffeic AcidsEpithelial-Mesenchymal TransitionProstatic NeoplasmsSnail Family Transcription FactorsAnimalsCell Line, TumorCell MovementGene Expression Regulation, NeoplasticHumansMaleMiceNeoplasm InvasivenessNeoplasm MetastasisSignal Transductioncaffeic acidCaffeic AcidsSNAI1 protein, humanSnail Family Transcription Factorscaffeic acid derivativesEMTMPMCAprostate cancerslugsnail

Identifiers

PMID41827887
PMCPMC12984751

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.