ArticleCells2026
MRCKα Is a Suppressor of GEF-H1/RhoA/MRTF Signaling in Tubular Cells.
Veroni S Sri Theivakadadcham, Qinghong Dan, Brian Wu, Shruthi Venugopal, Vida Maksimoska, Aysegul Yucel-Polat, Andras Kapus, Katalin Szászi
Abstract read
In one paragraphArticle in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
8 authors.
Veroni S Sri TheivakadadchamKeenan Research Centre for Biomedical Science of the St. Michael's Hospital, Unity Health Toronto, Toronto, ON M5B 1T8, Canada.
Qinghong DanKeenan Research Centre for Biomedical Science of the St. Michael's Hospital, Unity Health Toronto, Toronto, ON M5B 1T8, Canada.
Brian WuDepartment of Medicine, Queen's University, Kingston, ON K7L 3N6, Canada.
Shruthi VenugopalKeenan Research Centre for Biomedical Science of the St. Michael's Hospital, Unity Health Toronto, Toronto, ON M5B 1T8, Canada.ORCID 0009-0003-9290-0988 Vida MaksimoskaKeenan Research Centre for Biomedical Science of the St. Michael's Hospital, Unity Health Toronto, Toronto, ON M5B 1T8, Canada.
Aysegul Yucel-PolatKeenan Research Centre for Biomedical Science of the St. Michael's Hospital, Unity Health Toronto, Toronto, ON M5B 1T8, Canada.
Andras KapusKeenan Research Centre for Biomedical Science of the St. Michael's Hospital, Unity Health Toronto, Toronto, ON M5B 1T8, Canada.ORCID 0000-0002-6610-9530 Katalin SzásziKeenan Research Centre for Biomedical Science of the St. Michael's Hospital, Unity Health Toronto, Toronto, ON M5B 1T8, Canada.ORCID 0000-0002-2490-8422 Funding
CIHR PJT 162360CIHR PJT 180482CIHR PJT-180624Kidney Foundation of Canada 25KHRG-1416869St. Michael's Hospital Keenan PDF scholarshipSt. Michael's Hospital Keenan Professorship
6 · The paper itselfAbstract
Tubule-derived pro-fibrotic mediators are central for the development of kidney fibrosis. We previously showed that fibrotic stimuli activate and elevate GEF-H1 (
Indexed as
Kidney TubulesrhoA GTP-Binding ProteinRho Guanine Nucleotide Exchange FactorsSignal TransductionTrans-ActivatorsAnimalsCell LineFibrosisHumansMiceMyotonin-Protein KinaseProtein BindingTransforming Growth Factor beta1ARHGEF2 protein, humanMRTFA protein, humanMyotonin-Protein KinaserhoA GTP-Binding ProteinRho Guanine Nucleotide Exchange FactorsTrans-ActivatorsTransforming Growth Factor beta1ARHGEF2 (GEF-H1)fibrogenic mediatorsguanine nucleotide exchange factorkidney fibrosismyocardin-related transcription factorMyotonic Dystrophy Kinase-related Cdc42-binding kinase αRhoA signalingtubular cells
Identifiers
PMID41827880
PMCPMC12984664
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