ArticleCells2026
LRP1 in Adult-Born Neural Stem Cells Modulates Neurogenesis and Hippocampal Memory.
Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
Funding
Abstract
(1) Background: Adult neurogenesis within the hippocampus modulates hippocampal memory and is often dysregulated in diseases that cause memory dysfunction, notably Alzheimer's disease. We have discovered a novel modulator of hippocampal neurogenesis-low-density lipoprotein receptor-related protein 1 (LRP1). (2) Methods: Using an inducible knockout of LRP1, male and female mice were subject to loss of LRP1, specifically in adult-born neural stem cells at 3 months of age. (3) Results: After 6 months with the knockout, animals without LRP1 in adult-born neural stem cells displayed behavioral phenotypes consistent with deficits in working memory and hippocampal-mediated spatial memory. We also found that over time, increasing numbers of adult-born LRP1-knockout neurons were present, although those neurons were morphologically less complex with fewer dendrites than controls. Our data suggest that the increase in the total number of adult-born neurons 6 months after knockout is due to a subtle increase in hippocampal proliferation over time. (4) Conclusions: Altogether, our data suggest that LRP1 is an important and previously unknown regulator of hippocampal neurogenesis.
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