Evidence map›Paper›PMID 41827854›Full record

ArticleCells2026

TRPA1 Expressed by Hepatocytes and Liver Macrophages Does Not Mediate Inflammatory Infiltration and Steatosis in a Mouse Model of Chronic Alcohol-Induced Liver Injury.

Dorottya Luca Fehér, Ammar Al-Omari, Zoltán Sándor, Dániel Hegedüs, Balázs Gaszner, Veronika Szombati, András Fincsur, Viktória Kormos

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In one paragraph

Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Dorottya Luca FehérDepartment of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, H-7624 Pécs, Hungary.
Ammar Al-OmariDepartment of Cosmetic Science, Faculty of Allied Medical Sciences, Al-Ahliyya Amman University, Amman 19328, Jordan.ORCID 0009-0006-4175-9402
Zoltán SándorDepartment of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, H-7624 Pécs, Hungary.
Dániel HegedüsDepartment of Anatomy, Medical School, University of Pécs, H-7624 Pécs, Hungary.
Balázs GasznerDepartment of Anatomy, Medical School, University of Pécs, H-7624 Pécs, Hungary.ORCID 0000-0003-2830-2732
Veronika SzombatiDepartment of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, H-7624 Pécs, Hungary.
András FincsurDepartment of Pathology, Medical School, University of Pécs, H-7624 Pécs, Hungary.
Viktória KormosDepartment of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, H-7624 Pécs, Hungary.ORCID 0000-0002-3360-2425

Funding

Medical School, University of Pécs 008_2025_PTE_RK/36NKFI NKFI-146117Thematic Excellence Program 2021 Health Sub-program of the Ministry for Innovation and Technology in Hungary, within the framework of the EGA-16 project of Pécs University TKP2021-EGA-16
6 · The paper itself

Abstract

Transient receptor potential ankyrin 1 (TRPA1) is a non-selective cation channel, and its activator, the alcohol breakdown product acetaldehyde, plays a key role in the pathomechanism of alcoholic liver disease (ALD). We hypothesized that TRPA1 is expressed in the liver, can be activated by alcohol breakdown products, and plays a role in ALD. We aimed (1) to confirm the presence of TRPA1 in liver samples from C57BL6/J mice by RNAscope in situ hybridization combined with immunostaining, (2) to prove that alcohol breakdown products may activate human TRPA1 by calcium-imaging, and (3) to investigate the role of TRPA1 in a chronic continuous 20% alcohol drinking model involving

Indexed as

Fatty LiverHepatocytesInflammationLiverLiver Diseases, AlcoholicMacrophagesTRPA1 Cation ChannelAnimalsDisease Models, AnimalEthanolHumansMaleMiceMice, Inbred C57BLMice, KnockoutEthanolTRPA1 Cation ChannelTrpa1 protein, mouseacetaldehydeacetic acidALDALTASTAUDchronic alcohol consumptionethanolliverliver damage scoreTRPA1

Identifiers

PMID41827854
PMCPMC12984836

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.