Evidence map›Paper›PMID 41827829›Full record

ArticleCells2026

Isolation and Characterization of Marrow-Isolated Adult Multilineage Inducible (MIAMI) Cell-Derived Extracellular Vesicles Demonstrate Multifunctional Therapeutic Potential in Tissue Regeneration and Anti-Inflammatory Immunomodulation.

Michelle B R G Ley, H Thomas Temple, Alicia R Jackson, Thomas M Best, Dimitrios Kouroupis, Gianluca D'Ippolito

Abstract read
In one paragraph

Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Michelle B R G LeyDepartment of Biomedical Engineering, University of Miami, Miami, FL 33146, USA.ORCID 0000-0001-9346-7563
H Thomas TempleDepartment of Orthopedics, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.ORCID 0009-0005-7115-073X
Alicia R JacksonDepartment of Biomedical Engineering, University of Miami, Miami, FL 33146, USA.ORCID 0000-0003-3962-6652
Thomas M BestDepartment of Orthopedics, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.ORCID 0000-0003-2836-161X
Dimitrios KouroupisDepartment of Orthopedics, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.ORCID 0000-0002-3892-9013
Gianluca D'IppolitoDepartment of Biomedical Engineering, University of Miami, Miami, FL 33146, USA.ORCID 0009-0007-1790-6502

Funding

Foundation for the National Institutes of Health R21AR080388-02
6 · The paper itself

Abstract

Marrow-isolated adult multilineage inducible (MIAMI) cells are a subpopulation of mesenchymal stem/stromal cells (MSC) with enhanced self-renewal, multilineage plasticity, and anti-inflammatory properties, suggesting that their extracellular vesicles (MIA-EVs) may confer advantages over conventional MSC-EVs. MIAMI cells were transcriptionally profiled and expressed regenerative markers, including

Indexed as

Anti-Inflammatory AgentsBone Marrow CellsCell LineageExtracellular VesiclesImmunomodulationMesenchymal Stem CellsRegenerationAnimalsCell ProliferationHumansMicroRNAsAnti-Inflammatory AgentsMicroRNAscell-free therapyextracellular vesiclesimmunomodulationirradiationmesenchymal stem/stromal cellsMIAMI cellsmicroRNAosteosarcomaregenerative medicinewound healing

Identifiers

PMID41827829
PMCPMC12984998

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.